Marie-Alexandrine BOLZINGER

Professeur

  • Génie Pharmacotechnique

Formulation des systèmes dispersés – Pénétration cutanée – Dermopharmacie – Cosmétologie


Bureau 1 Université Claude Bernard Lyon 1, bât 308G ESCPE-Lyon, 43 bd du 11 Novembre 1918 G206 Villeurbanne 69622 France

Bureau 2 Laboratoire de Dermopharmacie et Cosmétologie – LAGEP UMR 5007 – ISPB 8 avenue Rockefeller Lyon cedex 08 69373 FRANCE

Téléphone bureau 1: 04 72 43 18 33Téléphone bureau 2: 04 78 77 71 12


Site internet: https://www.researchgate.net/profile/Marie-Alexandrine_Bolzinger

Bio

MA Bolzinger est pharmacien et docteur de l’Université René Descartes. Elle développe depuis son recrutement en 2002 au sein du LAGEP des projets au sein de l’équipe GEPHARM, en formulation de colloïdes innovants et développe les protocoles biopharmaceutiques appliqués à la peau (17 doctorants encadrés). Elle a été durant 10 ans expert dans le groupe « ingrédients » auprès de l’ANSM (Agence Nationale de Sécurité du Médicament et des Produits de Santé), dans le domaine des études biopharmaceutiques appliquées à la peau. Elle est souvent sollicitée pour rédiger des articles ou des chapitres de livres traitant de l’absorption cutanée des substances chimiques, au niveau national ou international. Elle est responsable du parcours Cosmétologie Industrielle (mention Ingénierie de la Santé) et directeur de l’Institut de Pharmacie Industrielle de Lyon.

M.-A. Bolzinger, is a pharmacist specialized in cosmetology and dermopharmacy, especially pharmaceutical formulation for the topical route of administration and biopharmaceutical research who has both an industrial experience as project manager and an academic experience as professor at the university. In 2002 she was recruited as assistant professor at the Faculty of Pharmacy of Lyon to teach Cosmetology. Simultaneously she joined the LAGEP (UMR-CNRS 5007) for its research in the development of innovative formulations applied to the skin. She was involved in the managerial staff of 18 Ph. D students. Finally, she joined the working group on cosmetic ingredients at the regulation agency (Agence Nationale de Sécurité du Médicament et des Produits de Santé ou ANSM) in 2003. She’s responsible for the master degree in industrial cosmetology and director of the Institute of Industrial Pharmacy of Lyon.

Skin Absorption of Anions: Part One. Methodology for In Vitro Cutaneous Absorption Measurements

date:2016
références bibliographiques:

Paweloszek, Raphaël, Stéphanie Briançon, Yves Chevalier, Nicole Gilon-Delepine, Jocelyne Pelletier, and Marie-Alexandrine Bolzinger. “Skin Absorption of Anions: Part One. Methodology for In Vitro Cutaneous Absorption Measurements.” 33, no. 7 (July 2016): 1564–75. https://doi.org/10.1007/s11095-016-1909-1.
Pages:1564-1575

Pharmaceutical Research

 

Antimicrobial films containing microparticles for the enhancement of long-term sustained release

date:2016
références bibliographiques:

Bile, Jessica, Marie-Alexandrine Bolzinger, Jean-Pierre Valour, Hatem Fessi, and Yves Chevalier. “Antimicrobial Films Containing Microparticles for the Enhancement of Long-Term Sustained Release.” 42, no. 5 (2016): 818–24. https://doi.org/10.3109/03639045.2015.1081237.
Pages:818-824

Drug Development and Industrial Pharmacy

 

Pickering emulsions for skin decontamination

date:2016
références bibliographiques:

Salerno, Alicia, Marie-Alexandrine Bolzinger, Pauline Rolland, Yves Chevalier, Denis Josse, and Stéphanie Briançon. “Pickering Emulsions for Skin Decontamination.” 34 (August 2016): 45–54. https://doi.org/10.1016/j.tiv.2016.03.005.
Pages:45-54

Toxicology in Vitro

 

Skin Absorption of Anions: Part Two. Skin Absorption of Halide Ions

date:2016
références bibliographiques:

Paweloszek, Raphaël, Stéphanie Briançon, Yves Chevalier, Nicole Gilon-Delepine, Jocelyne Pelletier, and Marie-Alexandrine Bolzinger. “Skin Absorption of Anions: Part Two. Skin Absorption of Halide Ions.” 33, no. 7 (July 2016): 1576–86. https://doi.org/10.1007/s11095-016-1898-0.
Pages:1576-1586

Pharmaceutical Research

 

Pickering emulsions stabilized by charged nanoparticles

date:2016
références bibliographiques:

Ridel, Laure, Marie-Alexandrine Bolzinger, Nicole Gilon-Delepine, Pierre-Yves Dugas, and Yves Chevalier. “Pickering Emulsions Stabilized by Charged Nanoparticles.” 12, no. 36 (2016): 7564–76. https://doi.org/10.1039/C6SM01465H.
Pages:7564-7576

Soft Matter

 

The parameters influencing the morphology of poly(É›-caprolactone) microspheres and the resulting release of encapsulated drugs

date:2015
références bibliographiques:

Bile, Jessica, Marie-Alexandrine Bolzinger, Charlène Vigne, Olivier Boyron, Jean-Pierre Valour, Hatem Fessi, and Yves Chevalier. “The Parameters Influencing the Morphology of Poly(É›-Caprolactone) Microspheres and the Resulting Release of Encapsulated Drugs.” 494, no. 1 (October 2015): 152–66. https://doi.org/10.1016/j.ijpharm.2015.07.068.
Pages:152-166

International Journal of Pharmaceutics

 

Skin toxicity of surfactants: Structure/toxicity relationships

date:2015
références bibliographiques:

Lémery, Emmanuelle, Stéphanie Briançon, Yves Chevalier, Claire Bordes, Thierry Oddos, Annie Gohier, and Marie-Alexandrine Bolzinger. “Skin Toxicity of Surfactants: Structure/toxicity Relationships.” 469 (March 2015): 166–79. https://doi.org/10.1016/j.colsurfa.2015.01.019.
Pages:166-179

Colloids and Surfaces A: Physicochemical and Engineering Aspects

 

Zinc oxide as a new antimicrobial preservative of topical products: Interactions with common formulation ingredients

date:2015
références bibliographiques:

Pasquet, Julia, Yves Chevalier, Emmanuelle Couval, Dominique Bouvier, and Marie-Alexandrine Bolzinger. “Zinc Oxide as a New Antimicrobial Preservative of Topical Products: Interactions with Common Formulation Ingredients.” 479, no. 1 (February 2015): 88–95. https://doi.org/10.1016/j.ijpharm.2014.12.031.
Pages:88-95

International Journal of Pharmaceutics

 

Skin delivery by block copolymer nanoparticles (block copolymer micelles)

date:2015
références bibliographiques:

Laredj-Bourezg, Faiza, Marie-Alexandrine Bolzinger, Jocelyne Pelletier, Jean-Pierre Valour, Marie-Rose Rovère, Batoule Smatti, and Yves Chevalier. “Skin Delivery by Block Copolymer Nanoparticles (block Copolymer Micelles).” 496, no. 2 (December 2015): 1034–46. https://doi.org/10.1016/j.ijpharm.2015.11.031.
Pages:1034-1046

International Journal of Pharmaceutics

 

Antimicrobial activity of zinc oxide particles on five micro-organisms of the Challenge Tests related to their physicochemical properties

date:2014
références bibliographiques:

Pasquet, Julia, Yves Chevalier, Emmanuelle Couval, Dominique Bouvier, Gaëlle Noizet, Cécile Morlière, and Marie-Alexandrine Bolzinger. “Antimicrobial Activity of Zinc Oxide Particles on Five Micro-Organisms of the Challenge Tests Related to Their Physicochemical Properties.” 460, no. 1–2 (January 2014): 92–100. https://doi.org/10.1016/j.ijpharm.2013.10.031.
Pages:92-100

International Journal of Pharmaceutics

 

Effectiveness of grafting modes of methoxycinnamate sunscreen onto silica particles

date:2014
références bibliographiques:

Noomane, Ayed, Souhaira Hbaieb, Marie-Alexandrine Bolzinger, Stéphanie Briançon, Yves Chevalier, and Rafik Kalfat. “Effectiveness of Grafting Modes of Methoxycinnamate Sunscreen onto Silica Particles.” 441 (January 2014): 653–63. https://doi.org/10.1016/j.colsurfa.2013.10.029.
Pages:653-663

Colloids and Surfaces A: Physicochemical and Engineering Aspects

 

The contribution of zinc ions to the antimicrobial activity of zinc oxide

date:2014
références bibliographiques:

Pasquet, Julia, Yves Chevalier, Jocelyne Pelletier, Emmanuelle Couval, Dominique Bouvier, and Marie-Alexandrine Bolzinger. “The Contribution of Zinc Ions to the Antimicrobial Activity of Zinc Oxide.” 457 (September 2014): 263–74. https://doi.org/10.1016/j.colsurfa.2014.05.057.
Pages:263-274

Colloids and Surfaces A: Physicochemical and Engineering Aspects

 

Hairy skin exposure to VX in vitro: Effectiveness of delayed decontamination

date:2013
références bibliographiques:

Rolland, P., M.-A. Bolzinger, C. Cruz, D. Josse, and S. Briançon. “Hairy Skin Exposure to VX in Vitro: Effectiveness of Delayed Decontamination.” 27, no. 1 (February 2013): 358–66. https://doi.org/10.1016/j.tiv.2012.08.014.
Pages:358-366

Toxicology in Vitro

 

Emulsions stabilized with solid nanoparticles: Pickering emulsions

date:2013
références bibliographiques:

Chevalier, Yves, and Marie-Alexandrine Bolzinger. “Emulsions Stabilized with Solid Nanoparticles: Pickering Emulsions.” 439 (December 2013): 23–34. https://doi.org/10.1016/j.colsurfa.2013.02.054.
Pages:23-34

Colloids and Surfaces A: Physicochemical and Engineering Aspects

 

Penetration of drugs through skin, a complex rate-controlling membrane

date:2012
références bibliographiques:

Bolzinger, Marie-Alexandrine, Stéphanie Briançon, Jocelyne Pelletier, and Yves Chevalier. “Penetration of Drugs through Skin, a Complex Rate-Controlling Membrane.” 17, no. 3 (June 2012): 156–65. https://doi.org/10.1016/j.cocis.2012.02.001.
Pages:156-165

Current Opinion in Colloid & Interface Science

 

Nanoparticles via Nanoprecipitation Process

date:2012
références bibliographiques:

Minost, Audrey, Jean Delaveau, Marie-Alexandrine Bolzinger, Hatem Fessi, and Abdelhamid Elaissari. “Nanoparticles via Nanoprecipitation Process.” 6, no. 3 (August 1, 2012): 250–58. doi:10.2174/187221112802652615.
Pages:250-258

Recent Patents on Drug Delivery & Formulation

 

Emulsions stabilized with organic solid particles

date:2012
références bibliographiques:

Laredj-Bourezg, Faiza, Yves Chevalier, Olivier Boyron, and Marie-Alexandrine Bolzinger. “Emulsions Stabilized with Organic Solid Particles.” 413 (November 2012): 252–59. https://doi.org/10.1016/j.colsurfa.2011.12.064.
Pages:252-259

Colloids and Surfaces A: Physicochemical and Engineering Aspects

 

Human scalp permeability to the chemical warfare agent VX

date:2011
références bibliographiques:

Rolland, P., M.-A. Bolzinger, C. Cruz, S. Briançon, and D. Josse. “Human Scalp Permeability to the Chemical Warfare Agent VX.” 25, no. 8 (December 2011): 1974–1980. doi:10.1016/j.tiv.2011.06.021.
Pages:1974-1980

Toxicology in Vitro

 

Confocal Raman Microspectroscopy for Evaluating the Stratum Corneum Removal by 3 Standard Methods

date:2011
références bibliographiques:

Förster, M., M.A. Bolzinger, M.R. Rovere, O. Damour, G. Montagnac, and S. Briançon. “Confocal Raman Microspectroscopy for Evaluating the Stratum Corneum Removal by 3 Standard Methods.” 24, no. 2 (2011): 103–112. doi:10.1159/000322306.
Pages:103-112

Skin Pharmacology and Physiology

 

Confocal Raman microspectroscopy of the skin

Confocal Raman spectroscopy is a technique with considerable potential for the non-invasive study of biological tissues and skin samples in vitro or in vivo. It can be used to study skin physiology and possible pathological conditions and to obtain data about molecular composition and the structure of skin, for example, water content, moisturization and changes in the skin barrier function can all be observed. In-depth measurements also allow biopharmaceutical studies, such as analyzing the rate of penetration of a drug and the biochemical changes that may be induced by an applied formulation. Confocal Raman microspectroscopy is now at such a stage of refinement that it opens up new vistas. The big leap forward in its ease of use enables this technology to be used as an analytical method by more and more non-specialist laboratories. This review gives an overview of the state of the art of this technology by presenting an update on the principles of Raman spectroscopy and then by looking at examples of new developments in in vivo and in vitro applications.

date:2011
références bibliographiques:

Förster, Matthias, Marie-Alexandrine Bolzinger, Gilles Montagnac, and Stéphanie Briançon. “Confocal Raman Microspectroscopy of the Skin.” 21, no. 6 (November–December 2011): 851–863. doi:10.1684/ejd.2011.1494.
Pages:851-863

European Journal of Dermatology: EJD

 

Ingredients Tracking of Cosmetic Formulations in the Skin: A Confocal Raman Microscopy Investigation

date:2011
références bibliographiques:

Förster, Matthias, Marie-Alexandrine Bolzinger, Delphine Ach, Gilles Montagnac, and Stephanie Briançon. “Ingredients Tracking of Cosmetic Formulations in the Skin: A Confocal Raman Microscopy Investigation.” 28, no. 4 (January 7, 2011): 858–872. doi:10.1007/s11095-010-0342-0.
Pages:858-872

Pharmaceutical Research

 

Microemulsion Microstructure Influences the Skin Delivery of an Hydrophilic Drug

date:2011
références bibliographiques:

Naoui, Wafa, Marie-Alexandrine Bolzinger, Bernard Fenet, Jocelyne Pelletier, Jean-Pierre Valour, Rafik Kalfat, and Yves Chevalier. “Microemulsion Microstructure Influences the Skin Delivery of an Hydrophilic Drug.” 28, no. 7 (March 25, 2011): 1683–1695. doi:10.1007/s11095-011-0404-y.
Pages:1683-1695

Pharmaceutical Research

 

Skin absorption studies of octyl-methoxycinnamate loaded poly(D,L-lactide) nanoparticles: Estimation of the UV filter distribution and release behaviour in skin layers

date:2010
références bibliographiques:

Vettor, M., S. Bourgeois, H. Fessi, J. Pelletier, P. Perugini, F. Pavanetto, and M. A. Bolzinger. “Skin Absorption Studies of Octyl-methoxycinnamate Loaded poly(D,L-lactide) Nanoparticles: Estimation of the UV Filter Distribution and Release Behaviour in Skin Layers.” 27, no. 3 (May 2010): 253–262. doi:10.3109/10717540903097770.
Pages:253-262

Journal of Microencapsulation

 

Skin absorption studies of octyl-methoxycinnamate loaded poly(D,L-lactide) nanoparticles: Estimation of the UV filter distribution and release behaviour in skin layers

date:2010
références bibliographiques:

Vettor, M., S. Bourgeois, H. Fessi, J. Pelletier, P. Perugini, F. Pavanetto, and M. A. Bolzinger. “Skin Absorption Studies of Octyl-Methoxycinnamate Loaded poly(D,L-Lactide) Nanoparticles: Estimation of the UV Filter Distribution and Release Behaviour in Skin Layers.” 27, no. 3 (May 2010): 253–62. doi:10.3109/10717540903097770.
Pages:253-262

Journal of Microencapsulation

 

rhEGF microsphere formulation and in vitro skin evaluation

date:2010
références bibliographiques:

Haushey, L. Al, M. A. Bolzinger, H. Fessi, and S. Briançon. “rhEGF Microsphere Formulation and in Vitro Skin Evaluation.” 27, no. 1 (January 2010): 14–24. doi:10.3109/02652040902749061.
Pages:14-24

Journal of Microencapsulation

 

Skin contamination by radiopharmaceuticals and decontamination strategies

date:2010
références bibliographiques:

Bolzinger, M.A., C. Bolot, G. Galy, A. Chabanel, J. Pelletier, and S. Briançon. “Skin Contamination by Radiopharmaceuticals and Decontamination Strategies.” 402, no. 1–2 (December 15, 2010): 44–49. doi:10.1016/j.ijpharm.2010.09.027.
Pages:44-49

International Journal of Pharmaceutics

 

Effects of solid particle content on properties of o/w Pickering emulsions

date:2010
références bibliographiques:

Frelichowska, Justyna, Marie-Alexandrine Bolzinger, and Yves Chevalier. “Effects of Solid Particle Content on Properties of O/w Pickering Emulsions.” 351, no. 2 (November 2010): 348–356. doi:10.1016/j.jcis.2010.08.019.
Pages:348-356

Journal of Colloid and Interface Science

 

Expression of estrogen-related receptor beta (ERRβ) in human skin

Skin is a non classical target tissue for estrogens, whose biological and mechanical properties are affected by the hormonal deprivation occurring at the menopause. Estrogen-related receptors (ERR), closely related to the estrogen receptors (ER), constitute a subfamily of orphan receptors, interfering with ER-mediated signalling pathways. The expression of ERRβ has been detected in only a few adult tissues so far, such as the prostate and the inner ear. Here, we demonstrate the expression of ERRβ in normal human skin. ERRβ was detected in human epidermis, in both keratinocytes and Langerhans cells, by immunohistochemistry. These results were validated on freshly extracted epidermal cells and on monolayer-cultured keratinocytes by RT-PCR and western blotting (WB), suggesting the implication of ERRβ in skin immunity and endocrine effects.

date:2010
références bibliographiques:

Krahn-Bertil, Elodie, Morgan Dos Santos, Odile Damour, Valérie Andre, and Marie-Alexandrine Bolzinger. “Expression of Estrogen-related Receptor Beta (ERRβ) in Human Skin.” 20, no. 6 (November–December 2010): 719–723. doi:10.1684/ejd.2010.1083.
Pages:719-723

European Journal of Dermatology: EJD

 

Pickering w/o emulsions: Drug release and topical delivery

date:2009
références bibliographiques:

Frelichowska, Justyna, Marie-Alexandrine Bolzinger, Jean-Pierre Valour, Hanna Mouaziz, Jocelyne Pelletier, and Yves Chevalier. “Pickering W/o Emulsions: Drug Release and Topical Delivery.” 368, no. 1–2 (February 2009): 7–15. doi:10.1016/j.ijpharm.2008.09.057.
Pages:7-15

International Journal of Pharmaceutics

 

Topical delivery of lipophilic drugs from o/w Pickering emulsions

date:2009
références bibliographiques:

Frelichowska, Justyna, Marie-Alexandrine Bolzinger, Jocelyne Pelletier, Jean-Pierre Valour, and Yves Chevalier. “Topical Delivery of Lipophilic Drugs from O/w Pickering Emulsions.” 371, no. 1–2 (April 2009): 56–63. doi:10.1016/j.ijpharm.2008.12.017.
Pages:56-63

International Journal of Pharmaceutics

 

Topical delivery of cosmetics and drugs. Molecular aspects of percutaneous absorption and delivery

Percutaneous penetration/permeation is a useful tool for obtaining qualitative and/or quantitative information on the amount of a drug, a cosmetic substance, or any chemical that may enter a skin compartment or the systemic circulation of the human body for pharmaceutical or cosmetic purposes, or for toxicological studies. In the latter case, the extent entering can then be taken into consideration in order to calculate the margin of safety using the NOAEL (No Observed Adverse Effect Level) of an appropriate repeated dose toxicity study with the respective substance. This paper is a short overview of various aspects of skin penetration/permeation of drugs or cosmetic agents. The literature reports numerous studies on skin structure and skin properties influencing drug/cosmetic agent permeation profiles and kinetic parameters. The extensive research concerning the skin structure for determining the key parameters of the penetration/permeation process is therefore described first. Mathematical models of the skin absorption process for a drug are then discussed. Finally new developments in pharmaceutical and cosmetic fields to enhance drug permeation or to modify the stratum corneum structure are considered.

date:2009
références bibliographiques:

Förster, Matthias, Marie-Alexandrine Bolzinger, Hatem Fessi, and Stephanie Briançon. “Topical Delivery of Cosmetics and Drugs. Molecular Aspects of Percutaneous Absorption and Delivery.” 19, no. 4 (July–August 2009): 309–323. doi:10.1684/ejd.2009.0676.
Pages:309-323

European Journal of Dermatology: EJD

 

Pickering emulsions with bare silica

date:2009
références bibliographiques:

Frelichowska, Justyna, Marie-Alexandrine Bolzinger, and Yves Chevalier. “Pickering Emulsions with Bare Silica.” 343, no. 1–3 (July 2009): 70–74. doi:10.1016/j.colsurfa.2009.01.031.
Pages:70-74

Colloids and Surfaces A: Physicochemical and Engineering Aspects