Jean-Pierre VALOUR

Responsable Service Ingénierie de Projets

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Bureau 1 LAGEP Université Claude Bernard Lyon 1, bât 308G ESCPE-Lyon, 43 bd du 11 Novembre 1918 G233 Villeurbanne 69622 France

Fax bureau 1: 04 72 43 18 60Téléphone bureau 1: 04 72 43 18 84

Drop size distribution monitoring of oil-in-water emulsions in SMX+ static mixers: Effect of operating and geometrical conditions

date:2017
références bibliographiques:

CHABANON, Elodie, Nida SHEIBAT -OTHMAN, O. Mdere, Jean-Pierre VALOUR, Sebastien URBANIAK, and F. Puel. “Drop Size Distribution Monitoring of Oil-in-Water Emulsions in SMX+ Static Mixers: Effect of Operating and Geometrical Conditions.” 92 (June 2017): 61–69. https://doi.org/10.1016/j.ijmultiphaseflow.2017.03.001.
Pages:61-69

International Journal of Multiphase Flow

 

Antimicrobial films containing microparticles for the enhancement of long-term sustained release

date:2016
références bibliographiques:

Bile, Jessica, Marie-Alexandrine Bolzinger, Jean-Pierre Valour, Hatem Fessi, and Yves Chevalier. “Antimicrobial Films Containing Microparticles for the Enhancement of Long-Term Sustained Release.” 42, no. 5 (2016): 818–24. https://doi.org/10.3109/03639045.2015.1081237.
Pages:818-824

Drug Development and Industrial Pharmacy

 

Preparation of liposomes at large scale using the ethanol injection method: Effect of scale-up and injection devices

date:2015
références bibliographiques:

Charcosset, Catherine, Audrey Juban, Jean-Pierre Valour, Sébastien Urbaniak, and Hatem Fessi. “Preparation of Liposomes at Large Scale Using the Ethanol Injection Method: Effect of Scale-up and Injection Devices.” 94 (February 2015): 508–15. https://doi.org/10.1016/j.cherd.2014.09.008.
Pages:508-515

Chemical Engineering Research and Design

 

Skin delivery by block copolymer nanoparticles (block copolymer micelles)

date:2015
références bibliographiques:

Laredj-Bourezg, Faiza, Marie-Alexandrine Bolzinger, Jocelyne Pelletier, Jean-Pierre Valour, Marie-Rose Rovère, Batoule Smatti, and Yves Chevalier. “Skin Delivery by Block Copolymer Nanoparticles (block Copolymer Micelles).” 496, no. 2 (December 2015): 1034–46. https://doi.org/10.1016/j.ijpharm.2015.11.031.
Pages:1034-1046

International Journal of Pharmaceutics

 

The parameters influencing the morphology of poly(É›-caprolactone) microspheres and the resulting release of encapsulated drugs

date:2015
références bibliographiques:

Bile, Jessica, Marie-Alexandrine Bolzinger, Charlène Vigne, Olivier Boyron, Jean-Pierre Valour, Hatem Fessi, and Yves Chevalier. “The Parameters Influencing the Morphology of Poly(É›-Caprolactone) Microspheres and the Resulting Release of Encapsulated Drugs.” 494, no. 1 (October 2015): 152–66. https://doi.org/10.1016/j.ijpharm.2015.07.068.
Pages:152-166

International Journal of Pharmaceutics

 

Preparation of liposomes at large scale using the ethanol injection method: Effect of scale-up and injection devices

date:2015
références bibliographiques:

Charcosset, Catherine, Audrey Juban, Jean-Pierre Valour, Sébastien Urbaniak, and Hatem Fessi. “Preparation of Liposomes at Large Scale Using the Ethanol Injection Method: Effect of Scale-up and Injection Devices.” 94 (2015): 508–15. doi:10.1016/j.cherd.2014.09.008.
Pages:508-515

Chemical Engineering Research and Design

 

Towards a One-Step Synthesis and Encapsulation of Acentric Iron Iodate (Fe(IO<SUB>3</SUB>)<SUB>3</SUB>) Nanocrystals via Inverse Miniemulsion

date:2014
références bibliographiques:

Ladj, Rachid, Mohamed M. Eissa, Jean-Pierre Valour, Yannick Mugnier, Ronan Le Dantec, Hatem Fessi, Marc Dubled, Christine Galez, and Abdelhamid Elaissari. “Towards a One-Step Synthesis and Encapsulation of Acentric Iron Iodate (Fe(IO<SUB>3</SUB>)<SUB>3</SUB>) Nanocrystals via Inverse Miniemulsion.” 6, no. 1 (January 1, 2014): 102–10. doi:10.1166/sam.2014.1685.
Pages:102-110

Science of Advanced Materials

 

Support vector machines combined to observers for fault diagnosis in chemical reactors

A hybrid data/model-based approach is proposed for fault detection and isolation for chemical reactions in jacketed stirred vessels. Using data-based methods in high nonlinear systems requires training data to include a wide range of varying operations to ensure correct fault isolation. If such data is not available, a model-based approach can be used to enhance fault isolation. But, observers require a relatively precise process model, which is also not always available. In this work, we propose to combine an observer with statistical data-based methods (support vector machines, SVM) for fault detection in order to avoid at the time precise process modelling (necessary for model-based approach) and great number of training data (necessary for data-based approach). An interesting case study that falls in this category is a chemical stirred tank reactor, with high nonlinear reactions. Therefore, a simplified process model is used as a starting point to develop an observer for fault isolation. The used process model is corrected using information from SVM when no fault is detected. The methodology is validated experimentally in lab-scale and pilot-scale polymerisation reactors. For processes with linear dynamics, model-free SVM classification was found sufficient to detect and isolate sensor and actuator faults.

date:2014
références bibliographiques:

SHEIBAT -OTHMAN, Nida, Nassim Laouti, Jean-Pierre Valour, and Sami Othman. “Support Vector Machines Combined to Observers for Fault Diagnosis in Chemical Reactors.” 92 (2014): 685–95. https://doi.org/10.1002/cjce.21881.
Pages:685-695

The Canadian Journal of Chemical Engineering

 

Support vector machines combined to observers for fault diagnosis in chemical teactors

date:2013
références bibliographiques:

Sheibat-Othman, Nida, Nassim Laouti, Jean-Pierre Valour, and Sami Othman. “Support Vector Machines Combined to Observers for Fault Diagnosis in Chemical Teactors.” (2013): n/a–n/a. doi:10.1002/cjce.21881.
Pages:n/a-n/a

The Canadian Journal of Chemical Engineering

 

Aminodextran-coated potassium niobate (KNbO3) nanocrystals for second harmonic bio-imaging

date:2013
références bibliographiques:

Ladj, Rachid, Thibaud Magouroux, Mohamed Eissa, Marc Dubled, Yannick Mugnier, Ronan Le Dantec, Christine Galez, Jean-Pierre Valour, Hatem Fessi, and Abdelhamid Elaissari. “Aminodextran-Coated Potassium Niobate (KNbO3) Nanocrystals for Second Harmonic Bio-Imaging.” 439 (December 2013): 131–37. https://doi.org/10.1016/j.colsurfa.2013.02.025.
Pages:131-137

Colloids and Surfaces A: Physicochemical and Engineering Aspects

 

In Situ Monitoring of Cocrystallization Processes – Complementary Use of Sensing Technologies

Two in situ process analytical technologies were used to investigate a cocrystallization process: a focused beam reflectance measurement probe and a video probe. The cocrystallizations were conducted batch-wise in a stirred thermostatted vessel with carbamazepine and nicotinamide. The experiments were started in three domains of the phase solubility diagram. When carbamazepine crystals were also formed, a solution mediated phase transition from carbamazepine crystals towards cocrystals was initiated by the addition of the cocrystallizing agent (nicotinamide crystals). As the carbamazepine crystals and the carbamazepine/nicotinamide cocrystals exhibit prism-like and needle-like habits, respectively, it was possible to discriminate between them with the two sensors. The mechanisms involved in the solution mediated phase transition were investigated.

date:2012
références bibliographiques:

Gagnière, E., F. Puel, D. Mangin, J.-P. Valour, A. Rivoire, J.-M. Galvan, O. Monnier, and J.-P. Klein. “In Situ Monitoring of Cocrystallization Processes – Complementary Use of Sensing Technologies.” 35, no. 6 (2012): 1039–44. https://doi.org/10.1002/ceat.201100711.
Pages:1039-1044

Chemical Engineering & Technology

 

Encapsulation of a pressure-sensitive adhesive by spray-drying: microparticles preparation and evaluation of their crushing strength

date:2012
références bibliographiques:

Gavory, Cécile, Robin Abderrahmen, Jean-Pierre Valour, Didier Chaussy, Mohamed Naceur Belgacem, Hatem Fessi, and Stéphanie Briançon. “Encapsulation of a Pressure-Sensitive Adhesive by Spray-Drying: Microparticles Preparation and Evaluation of Their Crushing Strength.” 29, no. 2 (March 2012): 185–93. https://doi.org/10.3109/02652048.2011.642014.
Pages:185-193

Journal of Microencapsulation

 

Improvement of an encapsulation process for the preparation of pro- and prebiotics-loaded bioadhesive microparticles by using experimental design

The purpose of this study was to design a new vaginal bioadhesive delivery system based on pectinate-hyaluronic acid microparticles for probiotics and prebiotics encapsulation. Probiotic strains and prebiotic were selected for their abilities to restore vaginal ecosystem. Microparticles were produced by emulsification/gelation method using calcium as cross-linking agent. In the first step, preliminary experiments were conducted to study the influence of the main formulation and process parameters on the size distribution of unloaded microparticles. Rheological measurements were also performed to investigate the bioadhesive properties of the gels used to obtain the final microparticles. Afterwards an experimental design was performed to determine the operating conditions suitable to obtain bioadhesive microparticles containing probiotics and prebiotics. Experimental design allowed us to define two important parameters during the microencapsulation process: the stirring rate during the emulsification step and the pectin concentration. The final microparticles had a mean diameter of 137μm and allowed a complete release of probiotic strains after 16h in a simulated vaginal fluid at +37°C.

date:2011
références bibliographiques:

Pliszczak, D, S Bourgeois, C Bordes, J P Valour, M A Mazoyer, A M Orecchioni, E Nakache, and P Lantéri. “Improvement of an Encapsulation Process for the Preparation of Pro- and Prebiotics-loaded Bioadhesive Microparticles by Using Experimental Design.” 44, no. 1–2 (September 18, 2011): 83–92. doi:10.1016/j.ejps.2011.06.011.
Pages:83-92

European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for Pharmaceutical Sciences

 

Microemulsion Microstructure Influences the Skin Delivery of an Hydrophilic Drug

date:2011
références bibliographiques:

Naoui, Wafa, Marie-Alexandrine Bolzinger, Bernard Fenet, Jocelyne Pelletier, Jean-Pierre Valour, Rafik Kalfat, and Yves Chevalier. “Microemulsion Microstructure Influences the Skin Delivery of an Hydrophilic Drug.” 28, no. 7 (March 25, 2011): 1683–1695. doi:10.1007/s11095-011-0404-y.
Pages:1683-1695

Pharmaceutical Research

 

Cocrystal formation in solution: Inducing phase transition by manipulating the amount of cocrystallizing agent

date:2011
références bibliographiques:

Gagnière, Emilie, Denis Mangin, Francois Puel, Jean-Pierre Valour, Jean-Paul Klein, and Olivier Monnier. “Cocrystal Formation in Solution: Inducing Phase Transition by Manipulating the Amount of Cocrystallizing Agent.” 316, no. 1 (2011): 118–25. doi:10.1016/j.jcrysgro.2010.12.027.
Pages:118-125

Journal of Crystal Growth

 

Novel polymerizable surfactants: synthesis and application in the emulsion polymerization of styrene

date:2010
références bibliographiques:

Mekki, Sofiane, Salima Saïdi-Besbes, Abdelhamid Elaïssari, Jean-Pierre Valour, and Aïcha Derdour. “Novel Polymerizable Surfactants: Synthesis and Application in the Emulsion Polymerization of Styrene.” 42, no. 5 (March 3, 2010): 401–5. doi:10.1038/pj.2010.8.
Pages:401-405

Polymer Journal

 

Pickering w/o emulsions: Drug release and topical delivery

date:2009
références bibliographiques:

Frelichowska, Justyna, Marie-Alexandrine Bolzinger, Jean-Pierre Valour, Hanna Mouaziz, Jocelyne Pelletier, and Yves Chevalier. “Pickering W/o Emulsions: Drug Release and Topical Delivery.” 368, no. 1–2 (February 2009): 7–15. doi:10.1016/j.ijpharm.2008.09.057.
Pages:7-15

International Journal of Pharmaceutics

 

Topical delivery of lipophilic drugs from o/w Pickering emulsions

date:2009
références bibliographiques:

Frelichowska, Justyna, Marie-Alexandrine Bolzinger, Jocelyne Pelletier, Jean-Pierre Valour, and Yves Chevalier. “Topical Delivery of Lipophilic Drugs from O/w Pickering Emulsions.” 371, no. 1–2 (April 2009): 56–63. doi:10.1016/j.ijpharm.2008.12.017.
Pages:56-63

International Journal of Pharmaceutics