Sandrine BOURGEOIS

Maître de Conférences

  • Génie Pharmacotechnique

Formulation et caractérisation de systèmes micro- et nanoparticulaires – Encapsulation Formulation et caractérisations de formes solides


Bureau 1 Université Claude Bernard Lyon 1, bât 308G ESCPE-Lyon, 43 bd du 11 Novembre 1918 G206 Villeurbanne 69622 France

Téléphone bureau 1: 04 72 43 18 33

Pectin gelation with chlorhexidine: Physico-chemical studies in dilute solutions

date:2016
références bibliographiques:

Lascol, Manon, Sandrine Bourgeois, Florence Guillière, Marie Hangouët, Guy Raffin, Pedro Marote, Pierre Lantéri, and Claire Bordes. “Pectin Gelation with Chlorhexidine: Physico-Chemical Studies in Dilute Solutions.” 150 (October 2016): 159–65. https://doi.org/10.1016/j.carbpol.2016.05.014.
Pages:159-165

Carbohydrate Polymers

 

Microencapsulation of rifampicin for the prevention of endophthalmitis: In vitro release studies and antibacterial assessment

date:2016
références bibliographiques:

Lee, Mi Yeon, Sandrine Bourgeois, Eyad Almouazen, Jocelyne Pelletier, François Renaud, Hatem Fessi, and Laurent Kodjikian. “Microencapsulation of Rifampicin for the Prevention of Endophthalmitis: In Vitro Release Studies and Antibacterial Assessment.” , March 2016. doi:10.1016/j.ijpharm.2016.03.026.

International Journal of Pharmaceutics

 

Formulation of orodispersible films for paediatric therapy: investigation of feasibility and stability for tetrabenazine as drug model

date:2016
références bibliographiques:

Senta-Loys, Zoé, Sandrine Bourgeois, Cyril Pailler-Mattei, Géraldine Agusti, Stéphanie Briançon, and Hatem Fessi. “Formulation of Orodispersible Films for Paediatric Therapy: Investigation of Feasibility and Stability for Tetrabenazine as Drug Model.” , September 2016. https://doi.org/10.1111/jphp.12627.

Journal of Pharmacy and Pharmacology

 

The Development, Physicochemical Characterisation and in Vitro Drug Release Studies of Pectinate Gel Beads Containing Thai Mango Seed Kernel Extract

date:2013
références bibliographiques:

Nithitanakool, Saruth, Pimolpan Pithayanukul, Sandrine Bourgeois, Hatem Fessi, and Rapepol Bavovada. “The Development, Physicochemical Characterisation and in Vitro Drug Release Studies of Pectinate Gel Beads Containing Thai Mango Seed Kernel Extract.” 18, no. 6 (June 3, 2013): 6504–20. doi:10.3390/molecules18066504.
Pages:6504-6520

Molecules

 

A safe and practical method for the preparation of 7α-thioether and thioester derivatives of spironolactone

date:2013
références bibliographiques:

Agusti, Géraldine, Sandrine Bourgeois, Nathalie Cartiser, Hatem Fessi, Marc Le Borgne, and Thierry Lomberget. “A Safe and Practical Method for the Preparation of 7α-Thioether and Thioester Derivatives of Spironolactone.” 78, no. 1 (January 2013): 102–7. https://doi.org/10.1016/j.steroids.2012.09.005.
Pages:102-107

Steroids

 

Mucoadhesion evaluation of polysaccharide gels for vaginal application by using rheological and indentation measurements

The influence of hyaluronic acid (HA) and fructooligosaccharides (FOS) addition on low methyl pectin (LMP) gelation has been investigated in order to produce adhesive gel-based microparticles suitable for the development of a vaginal delivery system of pro- and prebiotics. First, dynamic rheological measurements were performed on LMP/Ca(2+) gels with or without FOS and HA in presence or not of porcine stomach mucins. This rheological method is known to translate the interactions between polymer and mucins and then simulate the polymer bioadhesion potential. Nevertheless, as this method is disputed, in vitro and ex vivo indentation test measurements were also achieved in order to correlate the results obtained. Despite some different results, the overall tendency indicates that addition of HA and FOS enhanced the mucoadhesive properties of LMP gels. Moreover, gel-based microparticles obtained according to an emulsification/gelation method and composed by LMP 3% (w/v), FOS 5% (w/v) and HA 0.5% (w/v) displayed a mucoadhesive potential adapted to vaginal delivery system.

date:2012
références bibliographiques:

Pliszczak, D, C Bordes, S Bourgeois, P Marote, H Zahouani, S Tupin, C Pailler Mattei, and P Lantéri. “Mucoadhesion Evaluation of Polysaccharide Gels for Vaginal Application by Using Rheological and Indentation Measurements.” 92 (April 1, 2012): 168–174. doi:10.1016/j.colsurfb.2011.11.039.
Pages:168-174

Colloids and Surfaces. B, Biointerfaces

 

Development of a nanoparticle-based system for the delivery of retinoic acid into macrophages

date:2012
références bibliographiques:

Almouazen, Eyad, Sandrine Bourgeois, Ali Boussaïd, Pascale Valot, Celine Malleval, Hatem Fessi, Serge Nataf, and Stephanie Briançon. “Development of a Nanoparticle-Based System for the Delivery of Retinoic Acid into Macrophages.” 430, no. 1–2 (July 2012): 207–15. https://doi.org/10.1016/j.ijpharm.2012.03.025.
Pages:207-215

International Journal of Pharmaceutics

 

Nano-encapsulation of Vitamin D3 Active Metabolites for Application in Chemotherapy: Formulation Study and in Vitro Evaluation

date:2012
références bibliographiques:

Almouazen, Eyad, Sandrine Bourgeois, Lars Petter Jordheim, Hatem Fessi, and Stephanie Briançon. “Nano-Encapsulation of Vitamin D3 Active Metabolites for Application in Chemotherapy: Formulation Study and in Vitro Evaluation.” , December 8, 2012. doi:10.1007/s11095-012-0949-4.

Pharmaceutical Research

 

Improvement of an encapsulation process for the preparation of pro- and prebiotics-loaded bioadhesive microparticles by using experimental design

The purpose of this study was to design a new vaginal bioadhesive delivery system based on pectinate-hyaluronic acid microparticles for probiotics and prebiotics encapsulation. Probiotic strains and prebiotic were selected for their abilities to restore vaginal ecosystem. Microparticles were produced by emulsification/gelation method using calcium as cross-linking agent. In the first step, preliminary experiments were conducted to study the influence of the main formulation and process parameters on the size distribution of unloaded microparticles. Rheological measurements were also performed to investigate the bioadhesive properties of the gels used to obtain the final microparticles. Afterwards an experimental design was performed to determine the operating conditions suitable to obtain bioadhesive microparticles containing probiotics and prebiotics. Experimental design allowed us to define two important parameters during the microencapsulation process: the stirring rate during the emulsification step and the pectin concentration. The final microparticles had a mean diameter of 137μm and allowed a complete release of probiotic strains after 16h in a simulated vaginal fluid at +37°C.

date:2011
références bibliographiques:

Pliszczak, D, S Bourgeois, C Bordes, J P Valour, M A Mazoyer, A M Orecchioni, E Nakache, and P Lantéri. “Improvement of an Encapsulation Process for the Preparation of Pro- and Prebiotics-loaded Bioadhesive Microparticles by Using Experimental Design.” 44, no. 1–2 (September 18, 2011): 83–92. doi:10.1016/j.ejps.2011.06.011.
Pages:83-92

European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for Pharmaceutical Sciences

 

Skin absorption studies of octyl-methoxycinnamate loaded poly(D,L-lactide) nanoparticles: Estimation of the UV filter distribution and release behaviour in skin layers

date:2010
références bibliographiques:

Vettor, M., S. Bourgeois, H. Fessi, J. Pelletier, P. Perugini, F. Pavanetto, and M. A. Bolzinger. “Skin Absorption Studies of Octyl-methoxycinnamate Loaded poly(D,L-lactide) Nanoparticles: Estimation of the UV Filter Distribution and Release Behaviour in Skin Layers.” 27, no. 3 (May 2010): 253–262. doi:10.3109/10717540903097770.
Pages:253-262

Journal of Microencapsulation

 

Skin absorption studies of octyl-methoxycinnamate loaded poly(D,L-lactide) nanoparticles: Estimation of the UV filter distribution and release behaviour in skin layers

date:2010
références bibliographiques:

Vettor, M., S. Bourgeois, H. Fessi, J. Pelletier, P. Perugini, F. Pavanetto, and M. A. Bolzinger. “Skin Absorption Studies of Octyl-Methoxycinnamate Loaded poly(D,L-Lactide) Nanoparticles: Estimation of the UV Filter Distribution and Release Behaviour in Skin Layers.” 27, no. 3 (May 2010): 253–62. doi:10.3109/10717540903097770.
Pages:253-262

Journal of Microencapsulation

 

Development of a novel nanocapsule formulation by emulsion-diffusion combined with high hydrostatic pressure

date:2009
références bibliographiques:

Lee, Mi-Yeon, Sang-Gi Min, Sandrine Bourgeois, and Mi-Jung Choi. “Development of a Novel Nanocapsule Formulation by Emulsion-Diffusion Combined with High Hydrostatic Pressure.” 26, no. 2 (March 2009): 122–29. doi:10.1080/02652040802193006.
Pages:122-129

Journal of Microencapsulation