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55 documents



Magnetic particles for in vitro

Tienrat, a soutenu le 21 Avril 2017 (co-direction avec la Thailand).
Name: TANGCHAIKEEREE Tienrat
Graduate School:
Directors: A. ELaissari
Beginning of the thesis:15/04/2016
Expected end of the thesis:15/04/2017
Funding: Bourse thailande et France (GRG)

Collection : Steady thesis
Date : 2017




Skin penetration and decontamination of actinides

Mrs Anissa TAZRART defended her thesis on 14 March 2017 at CEA Saclay,

the jury was composed of :
Civilité Nom Prénom Grade/qualité Etablissement d’exercice Rôle
M. Eric ANSOBORLO Chercheur CEA Marcoule Rapporteur
M. Philippe BERARD DR CEA Fontenay-aux-Roses Examinateur
Mme Marie-Alexandrine
BOLZINGER
PU Université Lyon 1 Co encadrante
Mme Stéphanie BRIANÇON PU Université Lyon 1 Directrice de thèse
Mme Isabelle DUBLINEAU Chercheure – HDR IRSN Fontenay-aux-Roses Rapporteure
Mme Nina GRIFFITHS Chercheure – HDR CEA Arpajon Co encadrante
M. Olivier PIOT PU Université de Reims Rapporteur

Collection : Steady thesis
Date : 2017




Thesis: biodegradable microparticles morphology sponge for therapeutic applications and cosmétotextile

Nadiah Zafar is pleased to invite you to her thesis defense entitled:

“Biodegradable microparticles sponge morphology for therapeutic applications and cosmétotextile”

The defense will take place Monday, May 23, 2016 at 14h in the Jacques Bordet room.

Collection : Steady thesis
Date : 2016




Optimization of the Rankine Cycke and its use for trucks

  • Auteur : Vincent Grelet, Encadré par Pascal Dufour, Madiha Nadri
  • Soutenance prévue : Depuis le 1er octobre 2012
  • Financement : Thèse avec bourse CIFRE et Renault Trucks-Volvo

L’évolution croissante du prix des carburants ainsi que les normes antipollution de plus enplus drastiques obligent les fabricants de véhicules commerciaux à développer des solutions innovantes pour réduire la consommation de carburant. Dans cet objectif, comme une grande partie de l’énergie contenue dans le carburant est directement relâchée à l’ambient sous forme de chaleur, celle-ci peut être valorisée et transformée via un cycle thermodynamique secondaire. Dans ce cadre, l’importante utilisation du cycle de Rankine à travers le monde en font un candidat naturel pour une implémentation dans un véhicule. Mais contrairement à une utilisation stationnaire, de nombreux obstacles se dressent pour une intégration totale dans un poids lourd. De nombreuses études ont été menées ces trente dernières années afin de déterminer le potentiel réel d’un tel système une fois embarqué à bord d’un véhicule. Les nombreuses sources de chaleur valorisables, les contraintes inhérentes à l’application embarquée ou encore les forts régimes transitoires induits par l’utilisation du camion doivent mener à une optimisation à la fois de l’architecture du système ainsi que de son système de contrôle. L’optimisation du système mène à un choix en terme de sources chaudes et froides, de topologie, de fluide de travail ainsi que de dimensionnement des composants afin de maximiser les performances. Le système de contrôle joue lui un rôle primordial afin de tirer un bénéfice maximum d’un tel système connaissant ses limites physiques ainsi que d’assurer une utilisation efficace. Dans cette thèse, une méthodologie de conception d’un système de valorisation des rejets thermiques est proposée. En se basant sur des simulations du véhicule complet basées sur un modèle détaillé, les thématiques de la sélection du fluide de travail, des sources chaudes et froides ainsi que l’optimisation des composants et du cycle sont approchées. Par la suite, le problème de contrôle en ligne de la surchauffe à la sortie de l’évaporateur est formalisé. En tenant compte des contraintes numériques d’implémentation, différentes stratégies de commande sont mises en place, allant du contrôleur PID à des structures plus avancées telle que la commande prédictive par modèle ou une loi de commande basée sur un observateur. La plupart de ces stratégies sont validées expérimentalement sur un banc d’essai mis en place durant la thèse.

Monsieur Roberto CIPOLLONE, Professeur Université de l’Aquila – Italie

Monsieur Pascal DUFOUR, Maître de Conférences HDR Université Claude Bernard Lyon 1 (co-encadrant)

Monsieur Pierre DUYSINX, Professeur Université de Liège – Belgique

Monsieur Vincent LEMORT, Professeur Assistant Université de Liège – Belgique (co-encadrant)

Madame Madiha NADRI-WOLF, Maître de Conférences Université Claude Bernard Lyon 1 (co-encadrant)

Monsieur Sorin OLARU, Professeur des Universités SUPELEC Paris

Monsieur Nicolas PETIT, Professeur Ecole des MINES PatisTech

Monsieur Frank WILLEMS, Professeur Associé Université technique d’Eindhoven – Pays-Bas

et

Monsieur Thomas REICHE, Volvo Trucks Global Trucks Technology Advanced Technology and Research, Saint Priest, France (co-encadrant industriel)


Collection : Steady thesis
Date : 2016




Preparation for small and large liposomes encapsulating the essential oil of clove free…

  • Etudiant : SEEBALY Carine
  • Diplôme : Doctorante Co-tutelle Franco Libanaise
  • Durée d’encadrement : Octobre 2012 – Décembre 2015
  • Encadrement : Charcosset Catherine, Pr H. Greige (Université Libanaise)

« Préparation à petite et grande échelle des liposomes encapsulant l’huile essentielle de clou de girofle libre et sous forme de complexe d’inclusion dansl’hydroxypropyl-β-cyclodextrine: Caractérisation des nanostructures et évaluation de leur effet antioxydant »

qui aura lieu le 5 Janvier 2016 à 11h (heure Liban), donc 10h (heure Française) à l’Université Libanaise.

La soutenance se fera à l’université Lyon depuis la salle de visioconférence qui se trouve au sous-sol du bâtiment Braconnier, le Mardi 5 Janvier à 10h.

Collection : Steady thesis
Date : 2016




Thesis Robin LAFFICHER

Robin LAFFICHER a soutenu le 1er décembre 2016 (directeur de thèse François Puel)

Collection : Steady thesis
Date : 2016




Thesis: ” Evaluation of the efficacy of CeO2 for the degradation and skin decontamination of an organophosphorus compound, Paraoxon”


Alicia Salerno defend her thesis Monday, September 19 at 14 pm in the conference room of the library of the Rockefeller site.

Abstract:

The organophosphorus nerve agents form part of chemical agents which pose the NRBC threat (nuclear, radio, biological, chemical). These agents can get into the body by inhalation, ingestion or skin absorption. The main route of chemical agent contamination is skin penetration, especially for VX which is low volatile. Decontamination of unprotected skin areas is crucial to prevent excessive absorption of toxic. This work aimed at evaluating the ability of cerium oxide nanoparticles to adsorb and degrade organophosphorus compounds by using an organophosphorus pesticide, Paraoxon, and an in vitro model, pig-ear skin. The results showed that ceria, in powder form, degraded the Paraoxon but did not allow to reduce its absorption through the skin. Liquid forms containing ceria (aqueous suspension, Pickering emulsion) have been formulated in order to avoid the dispersion of particles in the air during its use. While liquid formulations allow more efficient removal of Paraoxon during decontamination process, the degradation activity of ceria was low. The influence of the synthesis conditions on the physicochemical properties of ceria linked to degradation efficiency of nanoparticles has been studied. The results showed that specific surface area is the key parameter and that the application protocol of decontaminants must be adapted.

Collection : Steady thesis
Date : 2016




Thesis: Adaptive observers for online identification and observation of linear systems.


C. Afri has the great pleasure to invite you to his defense of thesis titled:

“Adaptive Observers for Online Identification and Observation
Linear systems. “

The defense will take place on Tuesday, December 13, 2016, at 10:00 am
The amphitheater Grignard at the Victor GRIGNARD Building of the Campus de la Doua.

The jury will consist of:
Mme Sophie Tarbouriech, DR CNRS, LAAS-CNRS Rapporteur
Mr Gildas Besançon, Prof., GIPSA LAB Rapporteur
Mme Françoise Couenne, CR CNRS, LAGEP Examinatrice
Mr Bogdan Marinescu, Prof., IRCCyN Examinateur
Mr Pascal Dufour, Maître de Conférences, LAGEP Directeur de thèse
Mr Vincent Andrieu, CR CNRS, LAGEP Co-Encadrant
Mr Laurent Bako, Maître de Conférences, ECL-INSA Lyon Co-Encadrant

Abstract:
In this thesis, we study the problem of identification of a linear
dynamical system. First, we survey various methods that have been
developed in the literature. We focus more particularly on methods named
adaptive observers. Secondly we present an approach which combines
subspace identification methods and adaptive observers. This new method is
interesting since it allows us to identify MIMO systems in an arbitrary
basis. The convergence of this algorithm is demonstrated using the
persistent excitation notions. In the third chapter we introduce a new
method that is inspired from nonlinear Luenberger observers developed in
recent years. This new algorithm is different from the existing algorithms
since the parameters and the system status are estimated simultaneously.
We demonstrate the robustness of this approach. The convergence of the
algorithm is obtained if the system inputs satisfy a differential
excitation
hypothesis. All these algorithms are evaluated and implemented on an
experimental bench.

Keywords :

Dynamical model – Linear system – nonlinear system –State observer –
Adaptive observer – Subspace approach – Linear Luenberger observers –
Nonlinear Luenberger observers Linear model – Lyapunov stability.

Collection : Steady thesis
Date : 2016




Thesis: Development of the mixed hydroxypropyl-β-cyclodextrin / liposome system for the encapsulation of the constituents of essential oils

Riham GHARIB will support his thesis on December 13, 2016, 10:30 am, videoconference room of the University Lyon 1, Bâtiment Braconnier
Title of the thesis: Development of the mixed hydroxypropyl-β-cyclodextrin / liposome system for the encapsulation of the constituents of essential oils
Framing : Catherine Charcosset and Hélène Greige
Thesis in co-supervision with the Lebanese University

Collection : Steady thesis
Date : 2016




Thesis: Interaction of triterpenes with synthetic membranes and human albumin: Application to progestins and corticosteroids and to two pentacyclic structures

Rola Abboud is pleased to invite you to her thesis defense entitled “Interaction of triterpenes with synthetic membranes and human albumin: Application to progestins and corticosteroids and to two pentacyclic structures” under the direction of: Mme Hélène GREIGE and Mme Catherine CHARCOSSET.
 
The defense will take place on Thursday, December 1 at 2 pm in the amphitheater of the CNRS, 2 Avenue Albert Einstein, in Villeurbanne.

ABSTRACT
The triterpenoids are a large and structurally diverse group of natural products derived from squalene. Progesterone derivatives and glucocorticoids are a group of oxygenated triterpenes having a tetracyclic skeleton and identified for their therapeutic properties. Whereas, erythrodiol and uvaol are pentacyclic triterpenes, known for their beneficial effects on human diet. In this thesis, we studied their interaction with the membranes of lipid vesicles and with human serum albumin to better understand their pharmacological properties. We have prepared liposomes in the absence and presence of the mentioned molecules using the thin film hydration method. Differential scanning calorimetry (DSC), Raman spectroscopy, Fourier transform infrared spectroscopy (FTIR) and fluorescence polarization of 1,6-diphenyl- 1,3,5-hexatriene (DPH) were used to investigate the effect of triterpenes on the membrane fluidity.
Besides, we used fluorescence spectroscopy to study the binding of cholesterol, a series of progesterone derivatives and another series of glucocorticoids to albumin. Also, the binding of bilirubin (site I ligand) to albumin was studied in the absence and presence of the mentioned molecules. FTIR spectra of HSA and HSA-complexes were analyzed to evaluate the effect of a triterpene on the albumin secondary structure.
The results revealed that progesterone derivatives, glucocorticoids, erythrodiol and uvaol changed the physical properties of the bilayers. All the studied triterpenes interacted with the choline head group and the alkyl chains of phospholipids. Furthermore, the structural features control the interaction of triterpenes with the membrane and therefore modulate their effects on membrane fluidity.
Progesterone derivatives and glucocorticoids have been proven to bind moderately to albumin. Dydrogesterone showed the highest binding constant. Hydrophobic interactions and hydrogen bonds played a major role in stabilizing the complexes. Finally, our study demonstrated that cholesterol exhibited a much weaker interaction with albumin compared to progesterone derivatives and glucocorticoids.
Our work has led to a better understanding of triterpenes molecular mechanisms of their interaction with proteins and biological membranes and structural features controlling these interactions.

Keywords: Differential scanning calorimetry, erythrodiol, Fourier transform infrared spectroscopy, fluorescence polarization, fluorescence spectroscopy, glucocorticoids, liposomes, progesterone derivatives, Raman spectroscopy, uvaol.

Collection : Steady thesis
Date : 2016




Thesis: Orodispersible films of tetrabenazine for pediatric administration

Zoé is pleased to invite you to her thesis defense entitled “Orodispersible films of tetrabenazine for pediatric administration”. Under the direction of: Mr. Hatem FESSI and Mrs. Sandrine BOURGEOIS.
The defense will take place on Tuesday 20 December at 14:00 in the amphitheater of Nuclear Physics on the Doua domain.

ABSTRACT
During the last decade, various strategies to develop innovating oral dosage forms for pediatric population were investigated in order to improve treatment efficiency, safety and acceptability. Among these new delivery systems, orodispersible films (ODF) present a great potential to enhance patient compliance. In ODF, drug is dissolved or dispersed in a hydrophilic film-forming polymer. Once the ODF is in the mouth, polymeric matrix disintegrates releasing the drug for local or systemic action. In this study, ODF, produced with the solvent casting/evaporation method, were developed to administer a drug of interest for pediatric population, the tetrabetazine (TBZ). Physicochemical and biopharmaceutic characterizations showed that ODF allowed a major improvement of TBZ dissolution profile in simulated saliva, mainly due to the amorphous state of the drug in ODF. ODF were identified as amorphous solid dispersion (SD) composed of both amorphous TBZ and polymer matrix. We demonstrated that the choice of the polymer plays an important role to maintain initial properties of the system and amorphous state stability over the time. H-bonding formation between TBZ and polymer is essential to assure the preservation of TBZ amorphous state. Moreover, the incorporation of cyclodextrins (CD), by generating H-bonding with TBZ, has extended its stability. By synergic effect, this association produces an improvement of drug release leading to promote bioavailability. As they are easy to swallow and allow enhancing treatment efficiency, ODF appear as suitable delivery forms for pediatric patients.

Key words: Pediatric oral dosage forms; Orodispersible films; Tetrabenazine; Hydroxypropylmethylcellulose; Polyvinylpyrrolidone; Pullulan; Amorphous solid dispersions; Cyclodextrins.


Collection : Steady thesis
Date : 2016




Thesis: Predictive control and fault tolerant control system applied to wind trubine

  • PhD student name : Mohamed Benlahrache
  • End: 8 jully 2016
  • Supervisor :  Sami Othman (director), Nida Sheibat-Othman
  • Summary of the PhD study : Predictive control ; observers ; wind tubines ; parameter identification ; statistical methods

abstract
In this thesis, model predictive control (MPC) is used to control the wind turbine and to identify the faults that could occur. Since the computation time in the MPC strategy is high, its use in real time fast systems may become unfeasable. To overcome this difficulty, the MPC control inputs are parametrized by Laguerre functions (LMPC) or Kautz functions (KMPC). This
allowed decreasing the computation time by 33% compared to non-parametrized MPC. The min-max MPC approach is also considered in order to render the control strategy robust to parametric uncertainties and faults scenarios.

These control strategies are evaluated on a wind turbine model with a multi-input (pitch angle and generator torque) / multi- output (generator power and generator speed) control, with constraints on inputs and outputs. These results are discussed in Chapter IV.

In Chapter V, the Laguerre or Kautz parameterized MPC is reformulated with the objective of faults compensations. Indeed, if the faults are detected and estimated then it is possible to calculate the correction required to compensate these faults. This strategy becomes interesting from a wind turbine is operated with a controller that is not aimed to be changed for security or cost reasons, and the objective of the operator is only to compensate actuator or sensor faults. In these simulations, an available benchmark was used with the controller implemented in it.

Collection : Steady thesis
Date : 2016




Thesis: Synthesis latex magnetic submicron and functionality for applications in biosensor

TALHA Jamshaid is pleased to invite you to his thesis defense entitled:

“Magnetic submicron latex synthesis and functionalized for applications in biosensor.”

The defense will take place May 24, 2016 at 10 am in the ground floor in ISA
(You can easily approach the place by http://insa-lyon.fr/ 5, rue de la Doua 69100 Villeurbanne)

Composition du jury :
Madame Stéphanie BRIANÇON, Professeur des Universités
Université Claude Bernard Lyon 1
Monsieur Benjamin CARBONNIER, Professeur des Universités
Université Paris-Est
Monsieur Mohamed Mehdi CHEHIMI, Directeur de Recherche
CNRS Equipe SCP, Université Paris-Est
Monsieur Abdelhamid ELAISSARI, Directeur de Recherche
CNRS UMR 5007 LAGEP Villeurbanne
Monsieur Abdelhamid ERRACHID EL SALHI, Professeur des Universités
Université Claude Bernard Lyon 1
Monsieur Ali LAAYOUN, Chercheur
BioMérieux SA, Grenoble
Madame Salima SAIDI, Professeur
Université d’Oran – Algérie

Collection : Steady thesis
Date : 2016




Towards a better understanding and control of polymorphism.

Summary of the PhD study 

  • PhD student name: Y. TAHRI
  • Years :  01/2013 - 12/2015
  • Supervisors: Cotutelle entre l’Université Lyon 1 et l’Université Mohammed V de Rabat., E. GAGNIERE, D. MANGIN, T. BOUNAHMIDI (EMI, Université Mohammed V, Agdal-Rabat)

Defense: September 15 at 3 p.m. in Mohammdia Engineering School in Rabat.
I wish also to invite you to my presentation on Monday 26 September at 10
a.m. in the Jacques Bordet room in LAGEP. Looking forward seeing you.

Title :
Toward a better understanding of polymorph crystallization in solution: Experimental study and modeling using population balance equation and kinetic equations

Abstract :
The Ostwald rule of stages is conventionally used to explain the crystallization behavior of a polymorphic system. It states that the metastable phase first appears and undergoes a polymorphic transition toward the stable phase, in a second step. The Classical models, which only consider nucleation and growth, fail to reflect the kinetic advantage of the metastable phase formulated by Ostwald’s rule. Hence, this work intends to study and better understand the crystallization of a polymorphic system, taking into account the Ostwald ripening mechanism, usually neglected. A model compound, L-Glutamic acid, is chosen for the experimental study in agitated and stagnant conditions. Two numerical models, one based on the population balance equation and the other based on the kinetic equations, are developed to simulate the behavior of that polymorphic system, observed experimentally. A qualitative comparison between these two models is proposed. The model that relates the population balance equation does not permit correct implementation of all the mechanisms. Conversely, the model based on the kinetic equations highlights the effect of the ripening mechanism on the competition between the two polymorphic phases and allows us to propose a new explanation of the Ostwald rule of stages.

Collection : Steady thesis
Date : 2016




Transformation Induced during an Industrial Process (TIPI) direct compression: Polymorphic Transition of caffeine and physical properties of the tablets

Etudiant : Audrey JUBAN
Durée d’encadrement : 2013-2016
Encadrement : François PUEL (directeur) Stéphanie BRIANCON
Résumé de la thèse : compression directe de poudres pharmaceutiques, principe actif modèle : caféine, transitions polymorphiques
Abstract :

Direct compression process is widely used in the pharmaceutical industry for tablet manufacturing. This work is dedicated to the study of the polymorphic transformation induced by a direct compression process, and its impact on tablet mechanical properties. The main objective is to improve the understanding of the phase transition of caffeine Form I into Form II occurring during the direct compression process, and whether it has an impact on the tablet tensile strength. In this way, several studies have been conducted on the impact of operating conditions on the polymorphic transformation of a model active pharmaceutical ingredient (API) and on few physical properties of the tablets.

The use of a compression simulator Styl’One Classique (Médel’Pharm) and a fatigue equipment (Instron®) for the manufacture of tablets, allowed studying two process parameters (compression load and compression speed) and two formulation parameters (dilution of the API and nature of the diluent). Caffeine phase transitions have been evaluated by differential scanning calorimetry (DSC). Moreover, during several months after tableting, kinetic studies were conducted in order to observe the influence of these parameters on the polymorphic transition of the anhydrous caffeine Form I into Form II in tablets during storage. Finally, the analysis of the transition mechanism of this API was performed thanks to a stretched exponential law, derived from the Johnson-Melh-Avrami model.

The tensile strength of tablets (global property) was measured by a diametral compression test and their surface hardness (local property) by nanoindentation. A first predictive model for tablet tensile strength according to the caffeine content was developed. The compression cycle characteristics calculated from the data recording with the compression simulator allowed analyzing the behavior of different blends during the compression process. A second model for predicting the tensile strength was then established.

Collection : Steady thesis
Date : 2016




Wastewater treatment by freezing on cold wall

Student: Thouaiba HTIRA-EZZI
Period : nov 2012- janv 2016
Staff:: Denis Mangin (Director), Claudia Cogné, Emilie Gagnière
Keywords of the thesis:: This work aims at developing and optimizing a pilot crystallizer of wastewater treatment on a cooled wall. A statistical model has allowed quantifying the role of the process parameters affecting ice purity. Moreover, a numerical model has been developed to understand the thermophysical phenomena and to secure the scale-up.

Thouaiba Htira a soutenu sa thèse le 23 septembre à Lyon, à 10h dans l’amphithéâtre de la bibliothèque universitaire.

Collection : Steady thesis
Date : 2016




Antimicrobial agent microencapsulation for the development of functionalized primary containers.

  • Etudiant :  BILE Jessica
  • Diplôme : Thèse FUI
  • Durée d’encadrement :  Octobre 2012 – Octobre 2015
  • Encadrement : Chevalier yves, Bolzinger M.A.

Title
Antimicrobial agent microencapsulation for the development of functionalized primary containers.

Abstract
Nowadays there is an urgent need of cosmetic products containing low amounts of preservatives which represents a real technological challenge.
In this context, the primary container plays a key role and has to be source of proposals. The objective of this study is to realize an active
packaging containing coated thin films with embedded antimicrobial microparticles. The aim of this functionalized primary container is to
ensure the formulation preservation at specific areas which are prone to contaminations. Thanks to the localized action of the active packaging the
antimicrobial agent concentration into the bulk of the formulation will be reduced to the minimal amount necessary to ensure the product protection.
First, this work focused on the formulation of microparticles loaded with antimicrobial agent using the emulsion/solvent evaporation method. Several
morphologies have been obtained with non-smooth microparticles characterized by scars and defects, roughness and holes. The parameters
and the physico-chemical mechanisms involved in these morphological deteriorations have been identified and discussed. It has been shown that
the formulation and processing parameters as the polymer mass and molar mass, the surfactant as well as the speed and shear rate of the propeller
play a key role in the final microparticles surface states. This study proved that there is a competition between solvent evaporation and the
coalescence of emulsion droplets which is responsible for the morphological degradations. Following this study, the resulting microspheres loaded with phenylethyl alcohol were dispersed in a binder and coated as thin films of various thicknesses by the dip-coating method at the polyolefin surface. It has been measured that the use of microparticles slows the antimicrobial agent diffusion by increasing the number of polymeric matrices that have to be crossed in order to reach the external medium. Such thin films resulted in an antimicrobial agent delivery up to 3 months which is 15 times higher than the delivery
obtained for the non-encapsulated antimicrobial agent. The antimicrobial activity of the phenylethyl alcohol in an emulsion has also been investigated. The phenylethyl alcohol partition between the water phase, the oil phase and the micellar phase of an emulsion has been measured.
These results led to the development of a mathematical model calculating the fraction of free antimicrobial agent present in the aqueous phase. It has been correlated with emulsion dosages and microbiological measurements using the five microorganisms of the challenge test during 14 days. It has been demonstrated that calculations enable the prediction of the antimicrobial agent concentration needed to ensure the antimicrobial protection. In particular, this work proved that the phenylethyl alcohol quantity necessary for antimicrobial protection is respectively 1.6 and 4.3 times higher for a micellar solution and an emulsion compared to an aqueous solution.

Keywords
Microencapsulation by solvent evaporation, preservative, antimicrobial thin film, drug delivery, phenylethyl alcohol, antimicrobial active packaging

Collection : Steady thesis
Date : 2015




Filtration and drainage actinide oxalates: Modeling and Optimization

Summary of the PhD study 

  • PhD student name: D BOURCIER
  • Years :  2012-2015
  • Supervisors: F. PUEL, D. COLSON

The defense was held Wednesday, October 28, 2015 at 14h in the Small CPE Lyon Amphitheatre (located on the area of Doua, CPE building, 43 Boulevard du 11 Novembre 1918 69100 Villeurbanne).

The jury:
M. Eugène Vorobiev (PU – UTC Compiègne, Rapporteur)
M. Herve Muhr (Directeur de Recherches LRGP Nancy, Rapporteur)

M. Jean-Pierre Féraud (Ingénieur de Recherche, CEA Marcoule)
M. Didier Colson (MCU – UCBL)
M. François Puel (PU – UCBL et CentraleSupelec – Directeur de Thèse)
M. Pascal Ginisty (Dr – Responsable d’Etudes IFTS)
M. Roman Peczalski (PU – UCBL)
M. Nicolas Vigier (Dr – Areva NC)


Collection : Steady thesis
Date : 2015




STRUCTURE AND PHYSICOCHEMISTRY OF SURFACTANT, THEIR IMPACT ON SKIN TOXICITY, BARRIER FUNCTION AND SKIN MOISTURIZATION

  • Etudiant : Emmanuelle LEMERY
  • Devenir: CDD URGO
  • Soutenue le 23/03/2015
  • Encadrement : Bolzinger, Briançon Stéphanie

Creams, shampoo, soaps, shower gel, all these cosmetics products, daily used; have in common the presence of an essential raw material for their formulation: the surfactant or emulsifier. Those molecules are often in contact with the skin. Indeed, thanks to its special amphiphilic structure, surfactant helps the stabilization of emulsion, the foam production and brings detergent properties to cosmetic cleansers, solubilizing fat and dirt present at the skin surface. Those molecules can also interact with skin components.

One of the first evidence of the interaction between the surfactant and the skin is the clinical signs observed following a chronical or a long exposition to formula containing a high rate of surfactants. These molecules are now well-known to initiate irritant contact dermatitis and are real public health matters concerning professional diseases to detergents. However, considering the multitude of surfactants on the market, action mechanisms of surfactants on the skin are still not well known, especially for nonionic surfactants, widely used in skin care products and considered as very mild. Sodium lauryl sulfate, an anionic surfactant, is nowadays a model molecule widely studied.

Skin toxicity is often linked to the interaction of the surfactant with the skin proteins, charged molecules. According to that, ionic surfactants are considered to be the more toxic for the skin. Furthermore, the monomeric form of the surfactant is described to be the entity responsible for skin toxicity because it can easily insert into the lipid bilayers of the stratum corneum and reach the deeper layers of the skin compare to the micelles. The surfactant’s toxicity is also linked to its critical micellar concentration.

The aim of this research project was to improve the knowledge on several physicochemical properties of numerous surfactants classes to better understand their interactions and effects on the skin. Several levels of study have been developed. After a detailed physicochemical analysis of surfactants, in vitro experiments helped to evaluate the surfactant’s effect on skin toxicity. The barrier function of the skin was study (surface/detergent properties, lipid matrix organization and the evaluation of the lipid extraction by surfactants) through ex vivo experiments. Finally, skin hydration measurements were made in vivo.

Our studies showed a noteworthy toxicity of some nonionic surfactants, on the opposite, some ionic surfactants were very mild. Parameters known in literature such as CMC or the charges of the surfactants were questioned. Several explanations were highlighted considering the surfactant organization in water and its behavior on the skin barrier, bringing new areas for future research to have a better understanding of the effect of surfactant on the skin.

Moreover, skin toxicity could be linked to one of the three levels studied on skin barrier: the lipid matrix disorganization.


Collection : Steady thesis
Date : 2015




Thermodynamic approach for the control of a non-linear infinite-dimensional system: application to tubular reactors

This thesis will deal on Port Hamiltonian modeling, reduction and control of infinite dimensional thermodynamical system. In first time, the work will consist on the Port-Hamiltonian formulation of a benchmark tubular reactor. Then the stabilization will be proposed by using the passivity based approach and Thermodynamics issued Lyapunov functions.

  • Author : Weijun Zhou, direction de thèse : F. Couenne, B. Hamroun
  • Defense scheduled : septembre 2014
  • Defensed : 22/06/2015
  • Financed by allocation ministère

Jury:

  • Boussad Hamroun
  • Francoise Couenne
  • Denis Dochain
  • Bernhard Maschke
  • Laurent Lefevre
  • Didier Georges
  • Yann Le Gorrec

Abstract
The main objective of this thesis consists to investigate the problem of modelling and control of a nonlinear parameter distributed thermodynamic system: the tubular reactor. We address the control problem of this nonlinear system relying on the
thermodynamic properties of the process. This approach requires using the classical extensive variables as the state variables. We use the thermodynamic availability as well as the reduced thermodynamic availability (this function is formed from some terms of the thermodynamic availability) as Lyapunov functions in order to asymptotically stabilize the tubular reactor around a steady profile. The distributed temperature of the jacket is the control variable. Some simulations illustrate these results as well as the efficiency of the control in presence of perturbations.

Next we study the Port Hamiltonian representation of irreversible infinite dimensional systems. We propose a Stokes-Dirac structure of a reaction- diffusion system by means of the extension of the vectors of the flux and effort variables. We illustrate this approach on the example of the reaction diffusion system. For this latter we use the internal energy as well as the opposite of the entropy to obtain Stokes-Dirac structures. We propose also a pseudo-Hamiltonian representation for the two Hamiltonians. Finally we tackle the boundary control problem. The objective is to study the existence of solutions associated to a linearized model of the tubular reactor controlled to the boundary.

Keywords :
Infinite-dimensional systems, Tubular reactors, Irreversible Thermodynamics, Lyapunov function, Distributed control, Port Hamiltonian system


Collection : Steady thesis
Date : 2015




Development of nanoparticles containing sodium alendronate for osteoporosis application

  • Etudiant :  MILADI Karim
  • Diplôme : Doctorant Co-tutelle Franco tunisienne
  • Durée d’encadrement :  Octobre 2012 – Décembre 2015
  • Encadrement : A. Elaissar, H. FESSI
Dr-Chimie

The defense was held Friday, November 27, 2015 at 14:30 at the Jacques Bordet room.

The jury consists of

Dr. Gillian BARRATT, CNRS, Université Paris Sud, France, rapporteur
Pr. Sami BOUFI, Faculté des sciences de Sfax, Université de Sfax, Tunisie, rapporteur
Pr. Abderrahman BOURAOUI, Faculté de pharmacie de Monastir, Université de Monastir, Tunisie, examinateur
Dr. Abdelhamid ELAISSARI, CNRS, Université Claude Bernard-Lyon1, France, directeur de thèse
Pr. Hatem FESSI, CNRS, Université Claude Bernard-Lyon 1, France, co-directeur de thèse
Pr. Souad SFAR, Faculté de pharmacie de Monastir, Université de Monastir, Tunisie, co-directeur de thèse


Abstract:

Osteoporosis is the most frequent metabolic disease that affects bone. Many actives have been used as pharmacological treatment of this disease. However, bisphosphonates, especially, alendronate sodium, are indicated as first line regimen. Alendronate is highly efficient but presents low absorption after oral administration. Its solubility in water is 20 mg/ml. It has also poor bioavailability (0.6-0.7%). In addition, this active could lead to many side effects, which are mainly related to the esophagus, the stomach and the intestine. Such effects are linked to a local contact of drug crystals with the mucosa. Encapsulation of active molecules allowed the obtaining of many advantages over conventional pharmaceutical forms such as, bioavailability and tolerance enhancement. In the first part of our study, we managed to encapsulate alendronate sodium in poly--caprolactone nanoparticles via two techniques: nanoprecipitation and double emulsion. Obtained nanoparticles presented a spherical form. Their size ranged between 200 and 450 nm. The highest encapsulation efficiency value was 34% and was obtained via double emulsion technique. This confirms that double emulsion is more suitable for hydrophilic drugs encapsulation. In vitro release profile showed two phases: first phase of burst release and a second more prolonged phase. Mathematical modeling showed that alendronate in vitro release occurs by drug diffusion and polymer chain relaxation. In the second experimental part, we managed to find a more interesting alternative. In fact, we opted for the use of chitosan which is a natural hydrophilic polymer. One of the obtained advantages is the avoidance of organic solvents use. In addition, this approach allowed the enhancement of encapsulation efficiency as this value increased to 70%. The used technique is ionic gelation. It is a simple encapsulation technique that is based on the transformation of a dissolved polymer to a gel-like state. This is due to electrostatic interaction with the added polyanion. Obtained nanoparticles have spherical shape. Sizes ranged between 91 and 175 nm depending on investigated parameters. Overall in vitro release profile was similar to that obtained with the first study but the main advantage is the more rapid release. This could render in vivo application more possible. The prepared particles could present an interesting alternative for osteoporosis treatment by the oral route. In vivo studies in rats were carried out to assess bioavailability and gastrointestinal tolerance of these particles.

Collection : Steady thesis
Date : 2015




Dynamic modeling of a heat pump system coupled to a PCM storage tank – systemic approach and experimental validation

Le modèle qui sera développé permettra de connaître le comportement dynamique du dispositif complet et servira d’outil d’aide à la conception du système de commande de l’ensemble. Le modèle développé sera basé sur une approche thermodynamique et sur l’application des principes de conservation (matière, énergie, quantité de mouvement). Des expérimentations réalisées au CNAM et chez CIAT permettront de valider les résultats de simulation.

  • Auteur : Jing WU direction de thèse : C. Jallut, E. Gagnière
  • Soutenance  : 8 octobre 2015
  • Financement : ANR ACLIRSYS 2011-2015

Abstract

In the area of buildings refrigeration, the use of thermal energy storage coupled with heat pump is a significant way for reducing the operating costs and optimizing the design of equipment. A prototype of refrigeration-PCM (Phase Change Material) energy storage system is built and implemented within the framework of the project ACLIRSYS (Advanced Control for Low Inertia Refrigeration Systems), funded by the French National Research Agency. The objective of my PhD thesis is to propose a dynamical physical model for the complete system.

Within the evaporator and condenser of the heat pump, the refrigerant can be liquid, vapor or mixture of both, while the storage media can be solid, liquid or a mixture of both. Therefore, it is necessary to consider the discrete events associated to phase changes in order to solve the energy and mass balances in different configurations. In this work, static models are used for the compressor and the expansion valve of the heat pump. The heat exchangers of the heat pump and the storage models are based on a representation of the fluid flows by a cascade of Continuous Stirred Tank Reactors (CSTRs). In order to assure the continuity of system evolution, the switching mechanism between different configurations is established. This switching is performed by matrix operations, which permit to achieve a global and very compact representation of the system. The thermodynamic properties of the refrigerant and their partial derivatives are analytically determined by using an equation of state. Two versions of the model for the storage are proposed. A simplified version where the supercooling is assumed to take place at a constant temperature and a more detailed version based on the population balance equations.

Experimental data from the prototype has been used to validate the developed model. Experiments in transient states were performed by varying the operating conditions. These date relate to the functioning of the heat pump alone, the storage alone and the coupled system. A very good agreement between the numerical results and experimental data was obtained.

Collection : Steady thesis
Date : 2015




Emulsion polymerization of modeling stabilized inorganic particles

  • PhD student name : Barthélemy Brunier
  • Years : 2013-2016
  • Supervisor :  Nida Sheibat-Othman (director)
  • Summary of the PhD study : Pickering stabilisation ; Laponite ; particle size distribution ; modeling nucleation and coagulation

Cette thèse est réalisée dans la cadre du projet ANR PickEP, sous la direction de Nida Othman, Elodie Bourgeat- Lami (C2P2) et Yves Chevalier.

Un résumé du travail de thèse est joint à la fin de ce mail.

La soutenance se tiendra le vendredi 4 décembre 2015 à 14h dans l’Amphi Jussieu ( bâtiment DARWIN, campus de la Doua).

Les membres de jury sont :

Dr. Salima Boutti – Arkema
Pr Nathalie Le Sauze – Université Paul Sabatier (LGC)
Pr. Christophe Serra – Université de Strasbourg (ICPEES)
Dr. Laurent Falk – CNRS (LRGP)
Dr. Koffi Fiaty – Université Claude Bernard Lyon 1 (LAGEP)
Dr. Nida Sheibat-Othman – Université Claude Bernard Lyon 1 (LAGEP)
Dr. Elodie Bourgeat-Lami – Université Claude Bernard Lyon 1 (C2P2)
Dr. Yves Chevalier – Université Claude Bernard Lyon 1 (LAGEP)

Abstract:

The aim of the present project is to develop a methodology for fundamental modeling of surfactant-free emulsion polymerization processes stabilized by inorganic particles, referred to as Pickering emulsion polymerization.

Modeling emulsion polymerization systems requires modeling the particle size distribution (PSD), which is an important end-use property of the latex. This PSD includes sub-models dedicated to particle nucleation,
mass transfer between the different phases (monomer, radicals, stabilizer), and particle coagulation. These models should preferably be individually identified and validated experimentally.

The first main part of the work is dedicated to the experimental study. This part can be divided in three parts. The first part describes the adsorption of inorganic particles on polymer without reaction.
Multilayer adsorption was observed and B.E.T. isotherm was able to describe this adsorption. The adsorption was found to be enhanced at higher ionic strength. The adsorption dynamics were found fast and therefore clay partitioning
can be considered at equilibrium during polymerization. The second part concerned the investigation of different reaction parameters on the particles number and reaction rate in ab initio polymerizations. The effect of mixing, initial monomer concentration
and initiator concentration were considered. Optimization of these conditions was useful for the modeling part. The last part described the differences between several Laponite grades through the ab initio emulsion polymerization of styrene.

The second main part of the manuscript focused on the modeling of the Pickering emulsion polymerization. The population balance model and average number of radicals balance were adapted regarding the effect of inorganic particles.
The growth of the polymer particles was optimized by fitting the models of radicals’ entry and desorption described available in literature to the experimental data. No modification was needed, which allowed us to conclude that the clay had no influence on radical exchange.
However, Laponite stabilization played an important role in polymer particles production. Coagulative nucleation model was able to describe the nucleation rate and predict the total number of particles.

Collection : Steady thesis
Date : 2015




Nouvelles applications des nanoparticules organiques: de la vectorisation d’un mélange d’actifs à travers la peau jusqu’au développement d’un test de diagnostique in vitro de l’allergie aux parfums

  • Etudiant :  CORTIAL Angèle
  • Diplôme : Thèse MENRT
  • Durée d’encadrement :  oct 2014
  • Encadrement : Briançon S., Nicolas J.F. (INSERM U851)


Collection : Steady thesis
Date : 2015




Numerical simulation and experimental study of membrane chromatography for biomolecule separation

  • Etudiant :  TEEPAKORN Chalore
  • Diplôme : Doctorant Bourse Thaïlande
  • Durée d’encadrement :  Octobre 2012 – Décembre 2015
  • Encadrement : Charcosset Catherine, Koffi Fiaty

Chalore Tipakorn is pleased to invite you to his thesis defense entitled “Numerical simulation and experimental study of membrane chromatography for the separation of biomolecules.”

It will be held at 14:00 Wednesday, December 16, 2015, at the conference room of the University Library.
This thesis is done under the direction of Ms. Catherine and Mr. Koffi Fiaty Charcosset. For more details, you can find the thesis summary, below.

Abstract:

Membrane chromatography (MC) is an alternative to traditional resin packed columns chromatography. The solute mass transport in the membrane occurs in convective through-pores rather than in stagnant fluid inside the pores of the resins particles, which is limited by the slow diffusive transport. MC offers the main advantage of reducing diffusion phenomena, shorter residence time and lowered pressures drops, and thus, facilitates rapid purification of large quantities of molecules. A wide range of chromatographic membranes involving different molecules retention mechanisms (ion exchange, affinity, etc…) is now commercialized. Despite their success, the influence of the geometry of the membrane chromatography devices remains relatively unexplored from a theoretical point of view. This doctoral thesis is aimed to clarify some ambiguous points related to this technique.

Keywords:
Membrane chromatography, Ion exchange, Breakthrough curve, Dynamic binding capacity, Axial flow chromatography, Radial flow chromatography

Collection : Steady thesis
Date : 2015




Parametric identification in closed loop by an optimal control law based on observability analysis.

  • Auteur : Jun Qian, Encadré par Pascal Dufour, Madiha Nadri
  • Soutenance prévue : Depuis le 1er mars 2012
  • Financement : Thèse avec bourse CIFRE et Acsysteme

*Closed-loop parameter identification approach with an optimal control
based on the observability analysis *

For online parameter identification, the developed methods here allow to
design online and in closed loop optimal inputs that enrich the
information in the current experience. These methods are based on
real-time measurements of the process, on a dynamic nonlinear (or linear)
multi-variable model, on a sensitivity model of measurements with respect
to the parameters to be estimated and a nonlinear observer. Analysis of
observability and predictive control techniques are used to define the
optimal control which is determined online by constrained optimization.
Stabilization aspects are also studied (by adding fictitious constraints
or by a Lyapunov technique). Finally, for the particular case of a first
order linear system, the explicit control law is developed. Illustrative
examples are processed via the ODOE4OPE software : a bio-reactor, a
continuous stirred tank reactor and a delta wing. These examples help to
see that the parameter estimation can be performed with good accuracy in a
single and less costly experiment.

Keywords: Online closed loop parameter identification, model based
predictive control, observer, design of optimal experiment, observability,
sensitivity model.

Collection : Steady thesis
Date : 2015




Passivity Preserving Balanced Reduction for the Finite and Infinite Dimensional Port Hamiltonian Systems

  • Author :Yongxin WU, direction de thèse : B. Maschke, B. Hamroun
  • Defense scheduled : September 2015
  • Financed by: ANR-11-BS03-0002 project HAMECMOPSYS nov. 2011- nov. 2015

La soutenance s’est tenu le lundi 7 décembre 2015 à 10h30 dans l’Amphi Thémis 9 (situé au bâtiment Thémis).

Abstract:

In this thesis we have developed different structure preserving reduction methods for finite and infinite dimensional port Hamiltonian systems by using a balanced model reduction approach. In the first part we have defined a descriptor representation of port Hamiltonian systems with constraints. The balanced realization of the descriptor system has been used for reducing the port Hamiltonian descriptor system and conserving explicitly the constraint equations. In the second part, conditions have been derived on the weighting matrices of the LQG control problem such that the dynamical LQG controller is passive and has a port Hamiltonian realization. Two passive LQG control design methods have been suggested and one of them allows us to define a LQG balanced realization. Based on this realization, the effort constraint method has been used to reduce the LQG balanced port Hamiltonian system and obtain a reduced order passive LQG controller. In this way the closed-loop system is derived from the interconnection of 2 port Hamiltonian systems, hence the Hamiltonian structure has been preserved. In the third part, the proceeding results have been extended to a class of infinite dimensional port Hamiltonian system with bounded input operator. A passive LQG control design method for infinite dimensional port Hamiltonian system has been derived as by control by interconnection. Based on the balanced realization associated with this passive LQG control design, a finite dimensional approximation has been achieved and a reduced order passive LQG controller has been derived. As a consequence, the system in closed-loop with this reduced order LQG controller again admits a port Hamiltonian structure and satisfies the passivity.

Collection : Steady thesis
Date : 2015




PICKERING EMULSIONS: THEORETICAL APPROACH AND APPLICATIONS. INTERFACIAL PHYSICO-CHEMICAL ANALYSIS. OBTENTION OF PICKERING NANOEMULSIONS BY SPONTANEOUS EMULSIFICATION AND PICKERING AERATED EMULSIONS.

  • Etudiant :  RIDEL Laure
  • Diplôme : Doctorant Thèse MENRT
  • Durée d’encadrement :  Octobre 2012 – Octobre 2015
  • Encadrement : Chevalier yves, Bolzinger M.A.

PICKERING EMULSIONS: THEORETICAL APPROACH AND APPLICATIONS. INTERFACIAL PHYSICO-CHEMICAL ANALYSIS. OBTENTION OF PICKERING NANOEMULSIONS BY SPONTANEOUS EMULSIFICATION AND PICKERING AERATED EMULSIONS.

Summary :
Pickering emulsions are emulsions stabilized by solid particles in opposition to emulsifiers-stabilized emulsions. The stabilization of Pickering emulsions comes from a strong adsorption of solid particles at the oil-water interface that builds a rigid barrier against coalescence.

The aim of this work was to understand, develop and optimize methods for the fabrication of different types of Pickering emulsions stabilized by silica nanoparticles. Three mains axes can be exposed: (i) Firstly, a theoretical approach on the physico-chemical interfacial phenomena of Pickering emulsions stabilized by non-aggregated individual silica nanoparticles. Adsorption as mono- or multi-layers can be reached depending the Oil/Silica ratio. Two behaviors were observed: At high oil/silica mass ratio, the oil/water interface was covered by a monolayer of non-aggregated silica particles. Stable emulsions were stabilized by a monolayer of silica particles at 54% coverage of the oil droplets surface. Oil droplet diameter depends on formulation parameters. Adsorption as multilayers was reached at lower oil/silica mass ratio and oil droplet diameter depends on fabrication process. (ii) Droplets diameters could be reduced thanks to various processes in order to obtain Pickering nanoemulsions, also called NanoPickering. The first step was to test the viability of such emulsions using a high energy process (sonication). Then, a low energy process (nanoprecipitation) was used. Stable Pickering nanoemulsions can be made on more than one month. However, the oil quantity obtained in the final media is low (less than 1wt%). (iii) In parallel, a new application was developed allowing the formulation of Pickering aerated emulsions, totally stabilized by nanoparticles. Two types of Pickering whipped emulsions can be made. One which has high air content or one which has a stable height, thanks to a gelification phenomenon. This occurs after a macroscopic change of state.

All of these results confirm that Pickering emulsions offer the opportunity to discover new applications made by innovative processes. For instance, NanoPickering made by spontaneous emulsification, or Pickering whipped emulsion fully stabilized without emulsifiers. Moreover, theoretical approaches and interfacial phenomena studies are still current scientific questions.

KEY WORD: Pickering emulsions, Interfacial, Monolayer, Multilayer, Nanoemulsions, NanoPickering, Sonication, Nanoprecipitation, Ouzo Effect, Pickering aerated emulsions, Non-aggregated individual silica nanoparticles.

Collection : Steady thesis
Date : 2015




Preparation and Evaluation of submicron particles Theranostic for biomedical applications: imaging and therapy

  • Student: IQBAL Muhammad
  • Credit : Bourse Government of Pakistan
  • Degree: PhD Thesis Pakistan
  • coaching time October 2012 – December 2015
  • Framing: A. ELAISSARI

    “Preparation and Evaluation of submicron particles Theranostic for biomedical applications: imaging and therapy.”
    This thesis is done under the direction of Dr. Abdelhamid Elaissari and Professor Hatem Fessi.

    The defense will be held Friday, November 13, 2015 at 14h at the Jacques Bordet room.

    Summary
    The objective of this study was to prepare and characterize multifunctional submicron particles used simultaneously
    for the diagnosis and treatment of many life-threatening diseases such as cancer. To do this, a systematic study was conducted to understand the mécaniqmes involved and optimize the process parameters double-emulsion solvent evaporation for the preparation of these particles. For in vitro imaging, fluorescent polymeric nanoparticles were encapsulated in a degradable matrix polycaprolactone using the method of the double emulsion solvent evaporation. For imaging in vivo, colloidal gold nanoparticles have been prepared and encapsulated by the same method and perfectly
    characterized. Finally, theranostics application, the gold nanoparticles (as a contrast agent) and a molecular active (hydrophilic
    Nefopam and hydrophobic benzyl benzoate) were encapsualés simultaneously in polycaprolactone particles. These multifunctional particles were characterized and evaluated as in vitro model of cutaneous penetration.

    Collection : Steady thesis
    Date : 2015




Récupération d’énergie par cycle de Rankine à bord d’un véhicule : commande et gestion énergétique.

  • Auteur : Johan Peralez, Encadré par Pascal Dufour, Madiha Nadri
  • Soutenance prévue : Mercredi 25 février 2015 à 10h00 sur le site d’IFP Energies Nouvelles à Solaize
  • Financement : Thèse de l’IFPEN


Collection : Steady thesis
Date : 2015




The method by absorption with storage inter-seasonal solar intensified by the crystallization of the absorbent: research and thermodynamic characterization of new couples design the storage tank.

  • PhD student name: E. LEFEBVRE
  • Years :  10/2012 à 09/2015
  • Supervisors: E. GAGNIERE, D. MANGIN, S. BENNICI (IRCELYON), A. AUROUX(IRCELYON)

Emeline LEFEBVRE has the pleasure and honor to invite you to my thesis defense entitled “The method by absorption with storage inter-seasonal solar intensified by the crystallization of the absorbent: research and thermodynamic characterization of new couples design the storage tank. ” This thesis is made in the context of the ANR Project SEED (see summary below for details) under the direction of Aline AUROUX and Ms Simona Bennici of IRCELYON and Denis MANGIN and Mrs. Emilie GAGNIERE of LAGEP. The defense will be held Thursday, November 26, 2015 at 10am in the Amphi 7 Themis (Themis located in the building next to the building CPE).
ABSTRACT
The use of solar energy as a renewable energy has been widely demonstrated since many years. Thermal solar energy storage is an interesting way of reducing gas emissions. This storage can be achieved using water vapor absorption-desorption in a binary system with a desiccant salt. The innovation of this project is the crystallization of the salt solution as its temperature falls under the storage temperature to optimize the storage capacity. A previous work was realized using LiBr as absorbent. In spite of its interesting efficiency, two major drawbacks have been underlined: its price and its low storage capacity. This work is dedicated
to evaluate and characterize new potential candidates of absorbent usable in the industrial process. The first chapter presents a bibliography report of the various thermal energy processes. The second and third chapters display the thermodynamical properties of the selected binary systems, calculated from calorimetric and vapor pressure measurements, and calculated process parameters which lead to select the new absorbent. The fourth chapter is based on the study of the solid/liquid/gas equilibrium of the new binary system and of LiBr/H2O to characterize the crystallized phases in many different equilibrium states. Finally, the last chapter presents a preliminary study of the CFD modeling of the non-isothermal flow in the storage tank and the suggested geometries tested for the
crystallization of KHCOO in the storage tank.

Collection : Steady thesis
Date : 2015




Control of wind turbine

  • Auteur : Vu Hoang-Giang, Encadré par Hassan Hammouri,  Hamed Yahoui (Laboratoire Ampere)
  • Soutenance prévue : Depuis le 1er septembre 2011
  • Financement : Bourse vietnamienne
  • Devenir: Retour au Vietnam


Collection : Steady thesis
Date : 2014




Elaboration de particules hybrides et anisotropiques

  • Etudiant :CHARIYA Kaewsaneha
  • Devenir: Retour en Thaïlande
  • Soutenue le le 27 Février 2014 à Bangkok
  • Encadrement :  A.   ElaissariP.  Tangboriboonrat, D. Polpanich (Mahidol University BangkokThailand


Collection : Steady thesis
Date : 2014




L’encapsulation des biomolécules via la double émulsion

  • Etudiant :  IBRAHEEM Dima
  • Diplôme : Back in  Syrie
  • Soutenue/strong> :  07/05/2014
  • Encadrement : A. Elaissari, H.FESSI
Dr-Chimie


Collection : Steady thesis
Date : 2014




Manufacture of hybrid nanoparticles for dermal

- Student : Augustine LALLOZ

- Ecole doctorale : EDISS
- Staff: Pr Stéphanie Briancon/Pr Marie Alexandrine Bolzinger
( en cotutelle avec l’université de Montréal : Pr Patrice Hidlgen et Pr Xavier Banquy)
- début de thèse : 1ere inscription à l’UCBL en septembre 2015 (mais thèse
débutée depuis septembre 2014 à l’Université de Montréal)
- Soutenue : 31.08.2016

Collection : Steady thesis
Date : 2014




Microencapsulation par coacervation complexe des protéines du lactosérum et de la gomme d’acacia

  • Student: ACH Delphine
  • Graduate School: Chimie
  • Directors: Yves Chevalier et Stéphanie Briançon, Nicolas J.F. (INSERM U851)
  • Beginning of the thesis: Avril 2011
  • End of the thesis: : Soutenue en Octobre 2014
  • Funding: CIFRE


Collection : Steady thesis
Date : 2014




Principes actifs de type triterpenoïde issus de la plante Ecballium elaterium : mesure des propriétés de transport membranaire et purification

  • Etudiant :  HABIB Lamice
  • Diplôme : Doctorante Co-tutelle Franco Libanaise
  • Durée d’encadrement :  Octobre 2010 – Décembre 2013
  • Encadrement : Charcosset Catherine, Pr H. Greige (Université Libanaise)


Collection : Steady thesis
Date : 2014




Stabilization and hybrid systems

  • Auteur : Humberto Shein Shiromoto, Encadré par Vincent Andrieu, Christophe Prieur (GIPSA)
  • Soutenue : 23/06/2014
  • Financement : Bourse ministérielle de l’école doctorale de Grenoble


Collection : Steady thesis
Date : 2014




Study and modelling of a continuous precipitation process in liquid-liquid extraction column

Summary of the PhD study : Confidentiel

  • PhD student name: A AMOKRANE
  • Defensed : 14/05/2014
  • Actually :Post-doctorant à INSTN Cadarache
  • Supervisors: F..PUEL, J.P. KLEIN


Collection : Steady thesis
Date : 2014




« Etude des propriétés antimicrobiennes de l’oxyde de zinc »

  • Etudiant : Julia PASQUET
  • Devenir: CDI chez STRAND
  • Soutenue : 21/07/2014
  • Encadrement : Bolzinger M.A., Chevalier


Collection : Steady thesis
Date : 2014




Control of a distributed parameter process with moving interface: application to an extrusion process

The aim of the Ph.D. is the control of distributed parameters with a moving interface. Such systems appears for instance in models of extrusion processes. A simplified bi-zone model of such a process is used in this thesis. In the first part the well-posedness in the sense of existence of solutions is analyzed. In a second instance the control of the mass transport and position of the interface is suggested using a control model with state-dependent input-delay. Finally more general models re considered namely boundary port Hamitonian systems are extended in order to include a moving interface and the associated power-conjugated variables are defined.

  • Authors : Mamadou Diagne, Ph.D. advisors : B. Maschke, F. Couenne
  • Defense scheduled: May 2013
  • Financed by the Ministery of Higher education and Research


Collection : Steady thesis
Date : 2013




Coupling of Population Balance Modeling and Computational Fluid Dynamics for Turbulent Emulsification Systems

Breakage kernels; population balance modeling; monitoring by video probe; high pressure homogenizer; static mixers. Effect of dispersed phase viscosity; coupled population balance-CFD
  • PhD student name : Julian Per Becker
  • Years : 2010-2013
  • Supervisors :  Nida Sheibat-Othman (director), François Puel
  • Summary of the PhD study :


Collection : Steady thesis
Date : 2013




Elaboration de la silice magnétique pour applications diagnostics in vitro

  • Etudiant :  BITAR Ahmad
  • Diplôme : Doctorant Thèse Syrie
  • Encadrement : A. Elaissari
Dr-Chimie


Collection : Steady thesis
Date : 2013




Elimination des ions fluorures dans des eaux naturelles par de nouveaux procédés – Application au problème de la fluorose en Tunisie

  • Etudiant :  BEN NASR Anis
  • Diplôme : Doctorant Co-tutelle Franco tunisienne
  • Durée d’encadrement :  Octobre 2009 – 2013
  • Encadrement : Charcosset Catherine, Pr. R. Ben Amar


Collection : Steady thesis
Date : 2013




Emulsions de Pickering stabilisées par des particules biodégradables

  • Etudiant : Faiza LAREDJ
  • Diplôme : Thèse sur thématique prioritaire MENRT
  • Durée d’encadrement : 1 septembre 2009 – soutenance prévue en 2013
  • Encadrement : Chevalier Yves, Bolzinger M.A.
 Dr-Chimie


Collection : Steady thesis
Date : 2013




Encapsulation de molécules actives pour la fonctionnalisation de textiles

  • Etudiant :  JAAFAR MAALEJ Chiraz
  • Diplôme : Post-Doctorante (projet Texacti’v)
  • Durée d’encadrement :  Novembre 2012 – Novembre 2013
  • Encadrement : A. Elaissar, H. FESSI


Collection : Steady thesis
Date : 2013




Nanotheracel : développement de nanoparticules polymères pour le ciblage et la modulation de macrophages

  • Etudiant :  ALMOUAZEN Eyad
  • Diplôme : Thèse MENRT
  • Encadrement : Bourgeois S, Briançon S.


Collection : Steady thesis
Date : 2013




Préparation de nouvelles formes pharmaceutiques pour l’encapsulation de la vitamine E par contacteur à membrane

  • Etudiant :  LAOUANIAbdallah
  • Diplôme : Doctorant Thèse MENRT
  • Durée d’encadrement :  Octobre 2010 – Décembre 2013
  • Encadrement : Charcosset Catherine


Collection : Steady thesis
Date : 2013




Stochastic approach for the chemical network study in the reactions of hydrocraking of complex matrix

The aim of the thesis is to enable a better understanding of the macroscopic functioning of catalysts (the activity, the selectivity and the stability).The GC-2D coupled with kinetic models applied to complex matrices will help to understand the reaction mechanisms of the hydrocracking reactions in a batch reactor and therefore to propose innovative solutions for catalyst selection and choice of process parameters. The model will be based on distributions of populations and the kinetic model will be obtained by the application of a stochastic approach.

  • Author : Reynald HENRY, PhDdirection: M. Tayakout-Fayolle (IRCE), F. Couenne
  • Defense scheduled : Novembre 2013
  • Financed by: allocation ministère 


Collection : Steady thesis
Date : 2013




These of Honoré K. Ouoba : Convective drying of foodstuff : influence of size, form, cut and structure of matter

Members : F Zougmore, H Desmorieux

Collection : Steady thesis
Date : 2013




Un modèle physique multi-échelle pour l’analyse de l’électrolyse de l’eau dans des électrolyseurs à membrane échangeuse de protons (PEMWE) : des données ab-initio vers les observables macroscopiques.

La filière énergétique de l’hydrogène se réfère àla possibilitéd’utilisation de H2pour transporter et produire de l’énergie.Il existe différentes méthodespour obtenirH2, parmi elles, l’électrolyse de l’eau.Parmi les dispositifsexistants utilisés pourla production d’hydrogènepar électrolyse del’eau, les électrolyseurs à membrane échangeuse de protons (PEMWE) ont été très étudiés durant cesdernières années.L’objectifprincipal de cette thèseest de fournir unmodèle multi-échellepour l’analyse du fonctionnement desPEMWE. Pour atteindre cet objectif, nous utilisons différentestechniquesthéoriques et numériques, en raison des différentes échellesqui doivent être traitées. Cette thèsecomporte deux axesprincipaux :le premierconsiste en l’élaboration d’un modèle multi-échelletransitoirepour décrire le fonctionnementd’unPEMWE. Ce modèlecomprend une description détailléedes mécanismes chimiques élémentaires et des cinétiques associées au niveau des électrodes, une descriptiondu comportement de l’interface catalyseur-électrolyte àl’échelle nanométrique et une descriptionmicrostructuraledu transport desespèces chimiqueset des chargesau long des assemblages membrane électrodes (AME). Nous présentonsune étude d’impactdesdifférentsmatériaux catalytiquessurles performances des PEMWE et une étudede la sensibilitéaux conditions de fonctionnementà partirdes simulations numériques etlesrésultats sont discutés encomparaison avec les donnéesexpérimentales.Le deuxième axeestconsacré à l’étude détaillée des phénomènesà l’échelleatomique. Dans ce but,nous avons réalisé des calculs basés sur la théoriefonctionnelle de la densité(DFT) pour fournirune description détailléede l’adsorptionde l’eau surIrO2etRuO2, deux des catalyseursles plus utilisés dans un PEMWE.

  • Auteur : Luiz Fernando LOPES OLIVEIRA direction de thèse : C. Jallut (LAGEP) et A.A. Franco (CEA).
  • Soutenance prévue : 15 janvier 2013
  • Financement : collaboration CEA


Collection : Steady thesis
Date : 2013




Dehydration of theophylline: static gravimetric analysis and monitoring of a contact vacuum stirred bed drying by near infrared spectroscopy.

  • Doctorante : Amira TOUIL (Université de Lyon et Université de Gabès), directeurs : Roman PECZALSKI (Université de Lyon) et Fethi ZAGROUBA (Université de Carthage)

The aim of this work was to investigate the dehydration process of a single static layer of theophylline’s crystals under different hygrothermal conditions and the dehydration-drying process of a stirred bed of theophylline in a vacuum contact dryer in nearly the same hygrothermal conditions.
First of all, the hydrated and dehydrated forms of theophylline were identified using DSC, TGA and PXRD devices. Next, the static gravimetric experiments at constant temperature and relative humidity were carried out and the water content evolutions with time were recorded at temperatures from 20 to 80°C and humidities from 4 to 50%. Then, the thermodynamic equilibrium data were reported as desorption isotherms and solid-solid phase diagrams. Finally, the dehydration kinetics were analyzed. The dehydration rate constant was found to increase exponentially with temperature and to decrease exponentially with relative humidity. A simple semi-empirical model for prediction of the product water content evolution with time for different processing parameters was developed.

In the second part of the work, it was first proven that NIRS coupled with PLS regression enabled to monitor in-line and in-situ the exact composition of the mixture of different forms of theophylline (and of water) during drying. Second, the influence of operating parameters (temperature and water activity) on the kinetics of solid state transformations was investigated. It was observed that the dehydration begun by the formation of the metastable anhydrate and, after a time delay, continued by the formation of the stable one. It was also pointed out that the temperature was the main process factor controlling not only the overall process rate but also the final contents of the stable and metastable anhydrates, this observation being valid for the considered dryer and for the considered operating conditions.


Collection : Steady thesis
Date : 2012




Adsorption de CO2 à partir de gaz de synthèse : modélisation de la sélectivité, la capacité et la facilité de régénération de nouveaux adsorbants (CO2 adsorption from synthesis gas mixtures: understanding and Selectivity of new adsorbents)

The design of new environmentally friendly and efficient adsorbents for CO2 separation requires a quantitative link between the adsorbent properties and adsorption capabilities. One can use molecular simulations to generate an empirical correlation between some descriptors of the adsorbent, as the pore diameter, surface area, etc. with macroscopic properties, as the adsorbed amount at a given pressure. However, this approach requires a complete microscopic description of the adsorbent (atomic positions, intermolecular potentials, etc.) and demands a great number of time consuming simulations. In this work we develop a methodology, which explicitly takes into account the adsorbent properties, such as the pore diameter, density, pore shape and chemical composition. The objective is to establish quantitative correlations between the above-mentioned parameters and the forces that govern physisorption in porous media, i.e. van der Waals forces and electrostatic interactions. Thus, the optimal properties of the adsorbent for CO2 separation are identified. In parallel to these theoretical studies, a series of potentially interesting adsorbents for CO2 separation by PSA were tested experimentally. A systematic study of the influence of the metal center on the separations of CO2/CH4 and CO2/CH4/CO mixtures was carried out on MOFs presenting coordinatively unsaturated sites. In the case of zeolites, the effect of the framework composition (Si/Al ratio) on the separation properties was studied. The cyclic capacities and selectivities were determined by breakthrough experiments. Materials presenting a good compromise between selectivity and working capacity under typical PSA conditions were identified. Finally, a comparison between the prediction of the adsorption model and the breakthrough experiments is carried out.
  • Auteur : Edder GARCIA (IFPEN), direction de thèse : C. Jallut (LAGEP) – G. Pirngruber (IFPEN)
  • Soutenance : 22 octobre 2012
  • Financement : Collaboration IFPEN


Collection : Steady thesis
Date : 2012




Commande des procédés thermodynamiques irréversibles utilisant les systèmes hamiltoniens à port définis sur des pseudo structures de Poisson et des structures de contact



Collection : Steady thesis
Date : 2012




Form for Kids


Collection : Steady thesis
Date : 2012