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68 documents



A Multi-Models approach of Saint-Venant Equations

This paper deals with the stability study of the nonlinear Saint-Venant Partial Differential Equation (PDE). The proposed approach is based on the multi-model concept which takes into account some Linear Time Invariant (LTI) models defined around a set of operating points. This method allows describing the dynamics of this nonlinear system in an infinite dimensional space over a wide operating range. A stability analysis of the nonlinear Saint-Venant PDE is proposed both by using Linear Matrix Inequalities (LMIs) and an Internal Model Boundary Control (IMBC) structure. The method is applied both in simulations and real experiments through a microchannel, illustrating thus the theoretical results developed in the paper.
Dos Santos Martins, Valerie, Mickael Rodrigues, and Mamadou Diagne.
“A Multi-Models Approach of Saint-Venant Equations.” 22, no. 3 (2012): 539–50. doi:10.2478/v10006-012-0041-6.
Pages:539–550

Publication: International Journal of Applied Mathematics and Computer Science (AMCS)

Equipe : Multi-équipes
Date : 2012




A multiscale physical model for the transient analysis of PEM water electrolyzer anodes

Polymer electrolyte membrane water electrolyzers (PEMWEs) are electrochemical devices that can be used for the production of hydrogen. In a PEMWE the anode is the most complex electrode to study due to the high overpotential of the oxygen evolution reaction (OER), not widely understood. A physical bottom-up multi-scale transient model describing the operation of a PEMWE anode is proposed here. This model includes a detailed description of the elementary OER kinetics in the anode, a description of the non-equilibrium behavior of the nanoscale catalyst–electrolyte interface, and a microstructural-resolved description of the transport of charges and O2 at the micro and mesoscales along the whole anode. The impact of different catalyst materials on the performance of the PEMWE anode, and a study of sensitivity to the operation conditions are evaluated from numerical simulations and the results are discussed in comparison with experimental data.
Oliveira, Luiz Fernando L., Slimane Laref, Eric Mayousse, Christian Jallut, and Alejandro A. Franco.
“A Multiscale Physical Model for the Transient Analysis of PEM Water Electrolyzer Anodes.” 14, no. 29 (2012): 10215–24. doi:10.1039/c2cp23300b.
Pages:10215-24

Publication: Physical Chemistry Chemical Physics

Equipe : DYCOP
Date : 2012




A numerical model for predicting effective thermal conductivities of alumina/Al composites

Ferguen, Nabil, Claudia Cogné, Emmanuel Bellenger, Mohamed Guessasma, and Christine Pelegris.
“A Numerical Model for Predicting Effective Thermal Conductivities of alumina/Al Composites.” , 2012. doi:10.1177/0021998312464081.

Publication: Journal of Composite Materials

Equipe : PES
Date : 2012




A Review on Freeze-Drying of Drugs with tert-Butanol (TBA) + Water Systems: Characteristics, Advantages, Drawbacks

CRASTES-VESSOT, Séverine, and Julien Andrieu.
“A Review on Freeze-Drying of Drugs with Tert-Butanol (TBA) + Water Systems: Characteristics, Advantages, Drawbacks.” 30, no. 4 (2012): 377–85. doi:10.1080/07373937.2011.628133.
Pages:377-385

Publication: Drying Technology

Equipe : PES
Date : 2012




A versatile method for the preparation of rigid submicron hollow capsules containing a temperature responsive shell

Rahman, Md Mahbubor, and Abdelhamid Elaissari.
“A Versatile Method for the Preparation of Rigid Submicron Hollow Capsules Containing a Temperature Responsive Shell.” 22, no. 3 (2012): 1173. doi:10.1039/c1jm13882k.
Pages:1173

Publication: Journal of Materials Chemistry

Equipe : Génie Pharmacotechnique
Date : 2012




Argan Oil Nanoemulsions as New Hydrophobic Drug-Loaded Delivery System for Transdermal Application

Lococo, D., C. E. Mora-Huertas, H. Fessi, I. Zaanoun, and A. Elaissari.
“Argan Oil Nanoemulsions as New Hydrophobic Drug-Loaded Delivery System for Transdermal Application.” 8, no. 5 (October 1, 2012): 843–848. doi:10.1166/jbn.2012.1445.
Pages:843-848

Publication: Journal of Biomedical Nanotechnology

Equipe : Génie Pharmacotechnique
Date : 2012




Crystallization-in-emulsion process of a melted organic compound: In situ optical monitoring and simultaneous droplet and particle size measurements

Khalil, Abir, Francois Puel, Xavier Cosson, Olga Gorbatchev, Yves Chevalier, Jean-Marc Galvan, Alain Rivoire, and Jean-Paul Klein.
“Crystallization-in-Emulsion Process of a Melted Organic Compound: In Situ Optical Monitoring and Simultaneous Droplet and Particle Size Measurements.” 342, no. 1 (March 2012): 99–109. doi:10.1016/j.jcrysgro.2011.06.005.
Pages:99-109

Publication: Journal of Crystal Growth

Equipe : Multi-équipes
Date : 2012




Crystallization-in-emulsion process of a melted organic compound: In situ optical monitoring and simultaneous droplet and particle size measurements

Khalil, Abir, Francois Puel, Xavier Cosson, Olga Gorbatchev, Yves Chevalier, Jean-Marc Galvan, Alain Rivoire, and Jean-Paul Klein.
“Crystallization-in-emulsion Process of a Melted Organic Compound: In Situ Optical Monitoring and Simultaneous Droplet and Particle Size Measurements.” 342 (2012): 99–109.
Pages:99-109

Publication: Journal of Crystal Growth

Equipe : Multi-équipes
Date : 2012




Development of a nanoparticle-based system for the delivery of retinoic acid into macrophages

Almouazen, Eyad, Sandrine Bourgeois, Ali Boussaïd, Pascale Valot, Celine Malleval, Hatem Fessi, Serge Nataf, and Stephanie Briançon.
“Development of a Nanoparticle-Based System for the Delivery of Retinoic Acid into Macrophages.” 430, no. 1–2 (July 2012): 207–15. doi:10.1016/j.ijpharm.2012.03.025.
Pages:207-215

Publication: International Journal of Pharmaceutics

Equipe : Génie Pharmacotechnique
Date : 2012




Dynamic modeling of the reactive twin-screw co-rotating extrusion process: experimental validation by using inlet glass fibers injection response and application to polymers degassing

In this Article is described an original dynamic model of a reactive corotating twin-screw extrusion (TSE) process operated by the Rhodia Co. for the Nylon-66 degassing finishing step. To validate the model, dynamic experiments have been performed on a small-scale pilot plant. These experiments consist of a temporary injection of glass fibers at the inlet of the extruder after it has reached a given operating point. The outlet glass fibers mass fraction time variation is then measured. This experiment does not lead to the RTD measurement. As a matter of fact, due to the high quantity of glass fibers that is introduced, the behavior of the flow through the extruder is perturbed so that the glass fibers cannot be considered as an inert tracer. The dynamic model that we have published elsewhere (Choulak et al. Ind. Eng. Chem. Res.2004, 43, 7373–7382) is adapted to take into account this nonlinear behavior of the extruder with respect to the glass fibers injection and is favorably compared to experimental results. The description of the degassing operation is also included in the model. The model allows simulations of the complete dynamic behavior of the process. When the steady state is reached, the good position of the degassing vent with respect to the partially and fully filled zones positions can also be checked, thus illustrating the way the model can be used for design purposes.
Goma Bilongo, Tchicaya, Françoise Couenne, Christian Jallut, Yann Le Gorrec, and Audrey Di Martino.
“Dynamic Modeling of the Reactive Twin-Screw Co-Rotating Extrusion Process: Experimental Validation by Using Inlet Glass Fibers Injection Response and Application to Polymers Degassing.” 51, no. 35 (July 30, 2012): 11381–88. doi:10.1021/ie300698k.
Pages:11381–11388

Publication: Industrial & Engineering Chemistry Research

Equipe : DYCOP
Date : 2012




Dynamic modelling of a stopped flow fixed bed reactor for gas phase olefin polymerisation

Browning, B., I. Pitault, Nida SHEIBAT -OTHMAN, E. Tioni, V. Monteil, and T.F.L. McKenna.
“Dynamic Modelling of a Stopped Flow Fixed Bed Reactor for Gas Phase Olefin Polymerisation.” 207–8 (2012): 635–44. doi:10.1016/j.cej.2012.07.027.
Pages:635-644

Publication: Chemical Engineering Journal

Equipe : PES
Date : 2012




Elaboration of Argan Oil Nanocapsules Containing Naproxen for Cosmetic and Transdermal Local Application

Rosset, Valentina, Naveed Ahmed, I. Zaanoun, B. Stella, Hatem Fessi, and Abdelhamid Elaissari.
“Elaboration of Argan Oil Nanocapsules Containing Naproxen for Cosmetic and Transdermal Local Application.” 1, no. 2 (December 1, 2012): 218–24. doi:10.1166/jcsb.2012.1023.
Pages:218-224

Publication: Journal of Colloid Science and Biotechnology

Equipe : Génie Pharmacotechnique
Date : 2012




Electrochemical properties of gold electrodes functionalized by new pseudo-polyrotaxanes of polyaniline and chemically modified β-cyclodextrin inclusion complex

Mlika, R., S. Hbaieb, R. Ben Chaabene, Y. Chevalier, R. Kalfat, and H. Ben Ouada.
“Electrochemical Properties of Gold Electrodes Functionalized by New Pseudo-Polyrotaxanes of Polyaniline and Chemically Modified β-Cyclodextrin Inclusion Complex.” 162, no. 1–2 (February 2012): 186–92. doi:10.1016/j.synthmet.2011.11.029.
Pages:186-192

Publication: Synthetic Metals

Equipe : Génie Pharmacotechnique
Date : 2012




Electrokinetic properties of bare or nanoparticle-functionalized textile fabrics

Ripoll, Lionel, Claire Bordes, Pedro Marote, Sabrina Etheve, Abdelhamid Elaissari, and Hatem Fessi.
“Electrokinetic Properties of Bare or Nanoparticle-Functionalized Textile Fabrics.” 397 (March 2012): 24–32. doi:10.1016/j.colsurfa.2012.01.022.
Pages:24-32

Publication: Colloids and Surfaces A: Physicochemical and Engineering Aspects

Equipe : Génie Pharmacotechnique
Date : 2012




Electrokinetic properties of poly-ε-caprolactone-based nanoparticles prepared by nanoprecipitation and emulsification-diffusion methods: a comparative study

Mora-Huertas, C. E., F. Couenne, H. Fessi, and A. Elaissari.
“Electrokinetic Properties of Poly-ε-caprolactone-based Nanoparticles Prepared by Nanoprecipitation and Emulsification-diffusion Methods: a Comparative Study.” 14, no. 6 (June 4, 2012). doi:10.1007/s11051-012-0876-7.

Publication: Journal of Nanoparticle Research

Equipe : Multi-équipes
Date : 2012




Electrokinetic properties of poly-ε-caprolactone-based nanoparticles prepared by nanoprecipitation and emulsification-diffusion methods: a comparative study

Mora-Huertas, C. E., F. Couenne, H. Fessi, and A. Elaissari.
“Electrokinetic Properties of Poly-Ε-Caprolactone-Based Nanoparticles Prepared by Nanoprecipitation and Emulsification-Diffusion Methods: A Comparative Study.” 14, no. 6 (June 4, 2012). doi:10.1007/s11051-012-0876-7.

Publication: Journal of Nanoparticle Research

Equipe : Multi-équipes
Date : 2012




Emulsions stabilized with organic solid particles

Laredj-Bourezg, Faiza, Yves Chevalier, Olivier Boyron, and Marie-Alexandrine Bolzinger.
“Emulsions Stabilized with Organic Solid Particles.” 413 (November 2012): 252–59. doi:10.1016/j.colsurfa.2011.12.064.
Pages:252-259

Publication: Colloids and Surfaces A: Physicochemical and Engineering Aspects

Equipe : Génie Pharmacotechnique
Date : 2012




Encapsulation of a pressure-sensitive adhesive by spray-drying: microparticles preparation and evaluation of their crushing strength

Gavory, Cécile, Robin Abderrahmen, Jean-Pierre Valour, Didier Chaussy, Mohamed Naceur Belgacem, Hatem Fessi, and Stéphanie Briançon.
“Encapsulation of a Pressure-Sensitive Adhesive by Spray-Drying: Microparticles Preparation and Evaluation of Their Crushing Strength.” 29, no. 2 (March 2012): 185–93. doi:10.3109/02652048.2011.642014.
Pages:185-193

Publication: Journal of Microencapsulation

Equipe : Génie Pharmacotechnique
Date : 2012




Engineered Nanoparticulate Drug Delivery Systems: The Next Frontier for Oral Administration?

Diab, Roudayna, Chiraz Jaafar-Maalej, Hatem Fessi, and Philippe Maincent.
“Engineered Nanoparticulate Drug Delivery Systems: The Next Frontier for Oral Administration?” 14, no. 4 (July 6, 2012): 688–702. doi:10.1208/s12248-012-9377-y.
Pages:688-702

Publication: The AAPS Journal

Equipe : Génie Pharmacotechnique
Date : 2012




Fault detection and isolation in linear parameter-varying descriptor systems via proportional integral observer

The main contribution of this paper is the design of a polytopic unknown inputs proportional integral observer (UIPIO) for linear parameter-varying (LPV) descriptor systems. This observer is used for actuator fault detection and isolation. The proposed method is based on the representation of the LPV descriptor systems in a polytopic form. Its parameters evolve in an hypercube domain. The designed polytopic UIPIO is also able to estimate both the states and the unknown inputs of the LPV descriptor system. Stability conditions of such observer are expressed in terms of linear matrix inequalities. An example illustrates the performances of such polytopic UIPIO. Copyright © 2011 John Wiley & Sons, Ltd.
Hamdi, H., Mickael Rodrigues, C. Mechmeche, D. Theilliol, and N. Benhadj Braiek.
“Fault Detection and Isolation in Linear Parameter-Varying Descriptor Systems via Proportional Integral Observer.” 26, no. 3 (2012): 224–40. doi:10.1002/acs.1260.
Pages:224–240

Publication: International Journal of Adaptive Control and Signal Processing

Equipe : SNLEP
Date : 2012




Fault diagnosis for a class of descriptor linear parameter-varying systems

In this paper, a model-based fault estimation method for a particular class of discrete-time descriptor linear parameter-varying systems is developed. The main contribution of this work consists in the design of an observer that performs simultaneously both, the states estimation and the fault magnitude vectors, considered as unknown inputs. The conditions for the existence of such observer are given. Such conditions guarantee the observer stability and they are proved through a Lyapunov analysis combined with a linear matrix inequalities formulation. The fault estimation scheme is evaluated through numerical simulations. Copyright © 2011 John Wiley & Sons, Ltd.
Astorga-Zaragoza, C. M., D. Theilliol, J. C. Ponsart, and M. Rodrigues.
“Fault Diagnosis for a Class of Descriptor Linear Parameter-Varying Systems.” 26, no. 3 (2012): 208–23. doi:10.1002/acs.1259.
Pages:208–223

Publication: International Journal of Adaptive Control and Signal Processing

Equipe : SNLEP
Date : 2012




In Situ Monitoring of Cocrystallization Processes – Complementary Use of Sensing Technologies

Two in situ process analytical technologies were used to investigate a cocrystallization process: a focused beam reflectance measurement probe and a video probe. The cocrystallizations were conducted batch-wise in a stirred thermostatted vessel with carbamazepine and nicotinamide. The experiments were started in three domains of the phase solubility diagram. When carbamazepine crystals were also formed, a solution mediated phase transition from carbamazepine crystals towards cocrystals was initiated by the addition of the cocrystallizing agent (nicotinamide crystals). As the carbamazepine crystals and the carbamazepine/nicotinamide cocrystals exhibit prism-like and needle-like habits, respectively, it was possible to discriminate between them with the two sensors. The mechanisms involved in the solution mediated phase transition were investigated.
Gagnière, E., F. Puel, D. Mangin, J.-P. Valour, A. Rivoire, J.-M. Galvan, O. Monnier, and J.-P. Klein.
“In Situ Monitoring of Cocrystallization Processes – Complementary Use of Sensing Technologies.” 35, no. 6 (2012): 1039–44. doi:10.1002/ceat.201100711.
Pages:1039-1044

Publication: Chemical Engineering & Technology

Equipe : PES
Date : 2012




Inferential MIMO predictive control of the particle size distribution in emulsion polymerization

A new inferential 2-step multiple input/multiple output (MIMO) model predictive control (MPC) of the particle size distribution (PSD) in emulsion polymerization processes is proposed. The bulk-like model describing the PSD is used with the material balances of initiator, radicals, monomer and surfactant. The inferential 2-step control strategy uses two measurements available online (without delay): the concentration of surfactant in the aqueous phase by conductimetry, and the concentration of monomer by calorimetry. In a first step, the optimal trajectory of surfactant concentration leading to the target PSD is calculated offline. In a second step, a multivariable model predictive control manipulates online the monomer and surfactant flow rates in order to track the precalculated surfactant concentration trajectory and to maximise the monomer concentration in the polymer particles in a constrained set-point tracking. Two control strategies are compared (nonlinear MPC and linearized MPC) with and without modelling errors.
Da Silva, Bruno, Pascal Dufour, Nida SHEIBAT -OTHMAN, and Sami Othman.
“Inferential MIMO Predictive Control of the Particle Size Distribution in Emulsion Polymerization.” 38 (2012): 115–25. doi:10.1016/j.compchemeng.2011.11.003.
Pages:115-125

Publication: Computers & Chemical Engineering

Equipe : Multi-équipes
Date : 2012




Lipid-based carriers: manufacturing and applications for pulmonary route

Jaafar-Maalej, Chiraz, Abdelhamid Elaissari, and Hatem Fessi.
“Lipid-Based Carriers: Manufacturing and Applications for Pulmonary Route.” 9, no. 9 (September 2012): 1111–27. doi:10.1517/17425247.2012.702751.
Pages:1111-1127

Publication: Expert Opinion on Drug Delivery

Equipe : Génie Pharmacotechnique
Date : 2012




Liposome and niosome preparation using a membrane contactor for scale-up

Pham, Thi Thuy, Chiraz Jaafar-Maalej, Catherine Charcosset, and Hatem Fessi.
“Liposome and Niosome Preparation Using a Membrane Contactor for Scale-Up.” 94 (June 2012): 15–21. doi:10.1016/j.colsurfb.2011.12.036.
Pages:15-21

Publication: Colloids and Surfaces B: Biointerfaces

Equipe : Génie Pharmacotechnique
Date : 2012




Loading antifungal drugs onto silica particles grafted with cyclodextrins by means of inclusion complex formation at the solid surface

Hbaieb, Souhaira, Rafik Kalfat, and Yves Chevalier.
“Loading Antifungal Drugs onto Silica Particles Grafted with Cyclodextrins by Means of Inclusion Complex Formation at the Solid Surface.” 439, no. 1–2 (December 2012): 234–45. doi:10.1016/j.ijpharm.2012.09.035.
Pages:234-245

Publication: International Journal of Pharmaceutics

Equipe : Génie Pharmacotechnique
Date : 2012




Lyapunov-based control of non isothermal continuous stirred tank reactors using irreversible thermodynamics

Hoang, H., F. Couenne, C. Jallut, and Y. Le Gorrec.
“Lyapunov-Based Control of Non Isothermal Continuous Stirred Tank Reactors Using Irreversible Thermodynamics.” 22, no. 2 (February 2012): 412–22. doi:10.1016/j.jprocont.2011.12.007.
Pages:412-422

Publication: Journal of Process Control

Equipe : DYCOP
Date : 2012




Membrane emulsification: A promising alternative for vitamin E encapsulation within nano-emulsion

Laouini, Abdallah, Hatem Fessi, and Catherine Charcosset.
“Membrane Emulsification: A Promising Alternative for Vitamin E Encapsulation within Nano-Emulsion.” 423–24 (December 2012): 85–96. doi:10.1016/j.memsci.2012.07.031.
Pages:85-96

Publication: Journal of Membrane Science

Equipe : Génie Pharmacotechnique
Date : 2012




Methodology for the Study of Vacuum Gas Oil Hydrocracking Catalysts in a Batch Reactor – Coupling of GC-2D Data with Vapour-Liquid Equilibrium

Henry, Reynald, Melaz Tayakout-Fayolle, Pavel Afanasiev, Françoise Couenne, Gregory Lapisardi, Laurent J. Simon, and Vincent Souchon.
“Methodology for the Study of Vacuum Gas Oil Hydrocracking Catalysts in a Batch Reactor – Coupling of GC-2D Data with Vapour-Liquid Equilibrium.” 560–61 (August 2012): 207–13. doi:10.4028/www.scientific.net/AMR.560-561.207.
Pages:207-213

Publication: Advanced Materials Research

Equipe : DYCOP
Date : 2012




Modelling nitrate reduction in a flow-through catalytic membrane contactor: Role of pore confining effects on water viscosity

Nitrate hydrogenation has been largely considered as an eco-friendly strategy for nitrate abatement in drinking water to meet more and more stringent emission targets. Nitrate conversion on conventional Pd–Cu catalysts can be dramatically promoted in catalytic membrane reactors operating in flow-through configuration. In a previous study (Wehbe et al. [14]), we have reported an unexpected result: the nitrate conversion increases with the transmembrane flowrate when operating with mesoporous top layers (pore size < 10 nm), opposing to the expected inverse trend from basic Reactor Engineering concepts. Moreover, at a given flowrate, the catalytic activity increased with a reduction of the pore size. To provide a rationale on such effects, we present here a coupled model of concentration polarization and ionic solute transport within membrane pores. Mass transfer within the membrane top layer has been modelled using the extended Nernst–Planck equations (convection–diffusion–migration) combined with Donnan steric partitioning and dielectric exclusion at both membrane/solution interfaces. In addition to concentration polarization effects, a potential increase of the solvent viscosity under confinement, involving unexpectedly low ionic and hydrogen diffusivities under nanoconfinement, is argued as the underlying reason for such effects.
Pera-Titus, M., M. Fridmann, N. Guilhaume, and K. Fiaty.
“Modelling Nitrate Reduction in a Flow-through Catalytic Membrane Contactor: Role of Pore Confining Effects on Water Viscosity.” 401–2 (15, 2012): 204–16. doi:10.1016/j.memsci.2012.02.003.
Pages:204-216

Publication: Journal of Membrane Science

Equipe : SNLEP
Date : 2012




Modified double emulsion process as a new route to prepare submicron biodegradable magnetic/polycaprolactone particles for in vivo theranostics

Ahmed, Naveed, Millán Michelin-Jamois, Hatem Fessi, and Abdelhamid Elaissari.
“Modified Double Emulsion Process as a New Route to Prepare Submicron Biodegradable Magnetic/polycaprolactone Particles for in Vivo Theranostics.” 8, no. 8 (2012): 2554. doi:10.1039/c2sm06872a.
Pages:2554

Publication: Soft Matter

Equipe : Génie Pharmacotechnique
Date : 2012




Molecular Weight Effect on the Dissolution Behavior of Polystyrene Films Using Fluorescence Technique

Ugur, Saziye, M. Selin Sunay, Md. Mahbubor Rahman, and Abdelhamid Elaissari.
“Molecular Weight Effect on the Dissolution Behavior of Polystyrene Films Using Fluorescence Technique.” 1, no. 2 (December 1, 2012): 241–48. doi:10.1166/jcsb.2012.1027.
Pages:241-248

Publication: Journal of Colloid Science and Biotechnology

Equipe : Génie Pharmacotechnique
Date : 2012




Morphology control of magnetic latex particles prepared from oil in water ferrofluid emulsion

Braconnot, S., M. M. Eissa, and A. Elaissari.
“Morphology Control of Magnetic Latex Particles Prepared from Oil in Water Ferrofluid Emulsion.” 291, no. 1 (June 15, 2012): 193–203. doi:10.1007/s00396-012-2700-4.
Pages:193-203

Publication: Colloid and Polymer Science

Equipe : Génie Pharmacotechnique
Date : 2012




Mucoadhesion evaluation of polysaccharide gels for vaginal application by using rheological and indentation measurements

The influence of hyaluronic acid (HA) and fructooligosaccharides (FOS) addition on low methyl pectin (LMP) gelation has been investigated in order to produce adhesive gel-based microparticles suitable for the development of a vaginal delivery system of pro- and prebiotics. First, dynamic rheological measurements were performed on LMP/Ca(2+) gels with or without FOS and HA in presence or not of porcine stomach mucins. This rheological method is known to translate the interactions between polymer and mucins and then simulate the polymer bioadhesion potential. Nevertheless, as this method is disputed, in vitro and ex vivo indentation test measurements were also achieved in order to correlate the results obtained. Despite some different results, the overall tendency indicates that addition of HA and FOS enhanced the mucoadhesive properties of LMP gels. Moreover, gel-based microparticles obtained according to an emulsification/gelation method and composed by LMP 3% (w/v), FOS 5% (w/v) and HA 0.5% (w/v) displayed a mucoadhesive potential adapted to vaginal delivery system.
Pliszczak, D, C Bordes, S Bourgeois, P Marote, H Zahouani, S Tupin, C Pailler Mattei, and P Lantéri.
“Mucoadhesion Evaluation of Polysaccharide Gels for Vaginal Application by Using Rheological and Indentation Measurements.” 92 (April 1, 2012): 168–174. doi:10.1016/j.colsurfb.2011.11.039.
Pages:168-174

Publication: Colloids and Surfaces. B, Biointerfaces

Equipe : Génie Pharmacotechnique
Date : 2012




Multi-Input Multi-Output Integrated Ionic Polymer-Metal Composite for Energy Controls

Nishida, Gou, Motonobu Sugiura, Masaki Yamakita, Bernhard Maschke, and Ryojun Ikeura.
“Multi-Input Multi-Output Integrated Ionic Polymer-Metal Composite for Energy Controls.” 3, no. 1 (February 29, 2012): 126–36. doi:10.3390/mi3010126.
Pages:126-136

Publication: Micromachines

Equipe : DYCOP
Date : 2012




Multi-Stimuli Responsive Magnetic Core–Shell Particles: Synthesis, Characterization and Specific RNA Recognition

Rahman, Md Mahbubor, and Abdelhamid Elaissari.
“Multi-Stimuli Responsive Magnetic Core–Shell Particles: Synthesis, Characterization and Specific RNA Recognition.” 1, no. 1 (June 1, 2012): 3–15. doi:10.1166/jcsb.2012.1006.
Pages:3-15

Publication: Journal of Colloid Science and Biotechnology

Equipe : Génie Pharmacotechnique
Date : 2012




Nano-encapsulation of Vitamin D3 Active Metabolites for Application in Chemotherapy: Formulation Study and in Vitro Evaluation

Almouazen, Eyad, Sandrine Bourgeois, Lars Petter Jordheim, Hatem Fessi, and Stephanie Briançon.
“Nano-Encapsulation of Vitamin D3 Active Metabolites for Application in Chemotherapy: Formulation Study and in Vitro Evaluation.” , December 8, 2012. doi:10.1007/s11095-012-0949-4.

Publication: Pharmaceutical Research

Equipe : Génie Pharmacotechnique
Date : 2012




Nanocapsules prepared via nanoprecipitation and emulsification–diffusion methods: Comparative study

Mora-Huertas, Claudia Elizabeth, Olivier Garrigues, Hatem Fessi, and Abdelhamid Elaissari.
“Nanocapsules Prepared via Nanoprecipitation and Emulsification–diffusion Methods: Comparative Study.” 80, no. 1 (January 2012): 235–39. doi:10.1016/j.ejpb.2011.09.013.
Pages:235-239

Publication: European Journal of Pharmaceutics and Biopharmaceutics

Equipe : Génie Pharmacotechnique
Date : 2012




Nanoparticles via Nanoprecipitation Process

Minost, Audrey, Jean Delaveau, Marie-Alexandrine Bolzinger, Hatem Fessi, and Abdelhamid Elaissari.
“Nanoparticles via Nanoprecipitation Process.” 6, no. 3 (August 1, 2012): 250–58. doi:10.2174/187221112802652615.
Pages:250-258

Publication: Recent Patents on Drug Delivery & Formulation

Equipe : Génie Pharmacotechnique
Date : 2012




Nonlinear and locally optimal controllers design for input affine locally controllable systems

Sahnoun, Mariem, Vincent Andrieu, and Madiha Nadri.
“Nonlinear and Locally Optimal Controllers Design for Input Affine Locally Controllable Systems.” 85, no. 2 (February 2012): 159–70. doi:10.1080/00207179.2011.641159.
Pages:159-170

Publication: International Journal of Control

Equipe : SNLEP
Date : 2012




Nucleic acid sample preparation for in vitro molecular diagnosis: from conventional techniques to biotechnology

Rahman, Md Mahbubor, and Abdelhamid Elaissari.
“Nucleic Acid Sample Preparation for in Vitro Molecular Diagnosis: From Conventional Techniques to Biotechnology.” 17, no. 21–22 (November 2012): 1199–1207. doi:10.1016/j.drudis.2012.07.001.
Pages:1199-1207

Publication: Drug Discovery Today

Equipe : Génie Pharmacotechnique
Date : 2012




Observer Design for MIMO Non-Uniformly Observable Systems

The design of high gain observers is usually based on normal forms of observability. If the system is observable for every input (uniform observability), the gain of the observer does not required a solution to differential equation. For multiple input multiple output (MIMO) non-uniformly observable systems, we give here a sufficient condition that the input must satisfy in order to design an observer. Unlike uniformly observable systems, the observer gain of non-uniformly observable systems is derived from a Lyapunov differential equation.
Dufour, P., S. Flila, and H. Hammouri.
“Observer Design for MIMO Non-Uniformly Observable Systems.” 57, no. 2 (2012): 511–16. doi:10.1109/TAC.2011.2166667.
Pages:511-516

Publication: IEEE Transactions on Automatic Control

Equipe : SNLEP
Date : 2012




Optimization of Freeze-Drying Cycles of Pharmaceutical Organic Co-Solvent-Based Formulations Using the Design Space Methodology

Bogdani, Eni, Séverine CRASTES-VESSOT, and Julien ANDRIEU.
“Optimization of Freeze-Drying Cycles of Pharmaceutical Organic Co-Solvent-Based Formulations Using the Design Space Methodology.” 30, no. 11–12 (2012): 1297–1306. doi:10.1080/07373937.2012.689590.
Pages:1297-1306

Publication: Drying Technology

Equipe : PES
Date : 2012




Ordonnancement des cuves de décroissance dans un service de médecine nucléaire

Hallouard, F., D. Matanza, A. Foucher, H. Fessi, and M. Fraysse.
“Ordonnancement Des Cuves de Décroissance Dans Un Service de Médecine Nucléaire.” 47, no. 2 (July 4, 2012): 299–308. doi:10.1051/radiopro/2012014.
Pages:299-308

Publication: Radioprotection

Equipe : Génie Pharmacotechnique
Date : 2012




Output feedback stabilization of a one-dimensional wave equation with an arbitrary time delay in boundary observation

The stabilization with time delay in observation or control represents difficult mathematical challenges in the control of distributed parameter systems. It is well-known that the stability of closed-loop system achieved by some stabilizing output feedback laws may be destroyed by whatever small time delay there exists in observation. In this paper, we are concerned with a particularly interesting case: Boundary output feedback stabilization of a one-dimensional wave equation system for which the boundary observation suffers from an arbitrary long time delay. We use the observer and predictor to solve the problem: The state is estimated in the time span where the observation is available; and the state is predicted in the time interval where the observation is not available. It is shown that the estimator/predictor based state feedback law stabilizes the delay system asymptotically or exponentially, respectively, relying on the initial data being non-smooth or smooth. Numerical simulations are presented to illustrate the effect of the stabilizing controller.
Guo, Bao-Zhu, Cheng-Zhong Xu, and Hassan Hammouri.
“Output Feedback Stabilization of a One-Dimensional Wave Equation with an Arbitrary Time Delay in Boundary Observation.” 18, no. 01 (2012): 22–35. doi:10.1051/cocv/2010044.
Pages:22-35

Publication: ESAIM: Control, Optimisation and Calculus of Variations

Equipe : SNLEP
Date : 2012




Oxalate Precipitation in Emulsion: from the Drop Scale to the Industrial Process

Amokrane, Abdenour, Amine Kacem, Sophie Charton, Francois Puel, and Jean-Paul Klein.
“Oxalate Precipitation in Emulsion: From the Drop Scale to the Industrial Process.” 7 (2012): 456–59. doi:10.1016/j.proche.2012.10.069.
Pages:456-459

Publication: Procedia Chemistry

Equipe : PES
Date : 2012




Penetration of drugs through skin, a complex rate-controlling membrane

Bolzinger, Marie-Alexandrine, Stéphanie Briançon, Jocelyne Pelletier, and Yves Chevalier.
“Penetration of Drugs through Skin, a Complex Rate-Controlling Membrane.” 17, no. 3 (June 2012): 156–65. doi:10.1016/j.cocis.2012.02.001.
Pages:156-165

Publication: Current Opinion in Colloid & Interface Science

Equipe : Génie Pharmacotechnique
Date : 2012




Pharmacokinetic study of an oral piroxicam formulation containing different molar ratios of β-cyclodextrins

Skiba, M., F. Bouchal, T. Boukhris, F. Bounoure, H. Fessi, S. Fatmi, N. Chaffai, and M. Lahiani-Skiba.
“Pharmacokinetic Study of an Oral Piroxicam Formulation Containing Different Molar Ratios of Β-Cyclodextrins.” 75, no. 3–4 (June 9, 2012): 311–14. doi:10.1007/s10847-012-0166-0.
Pages:311-314

Publication: Journal of Inclusion Phenomena and Macrocyclic Chemistry

Equipe : Génie Pharmacotechnique
Date : 2012




Polymer particle adsorption at textile/liquid interfaces: a simple approach for a new functionalization route

Ripoll, Lionel, Claire Bordes, Pedro Marote, Sabrina Etheve, Abdelhamid Elaissari, and Hatem Fessi.
“Polymer Particle Adsorption at Textile/liquid Interfaces: A Simple Approach for a New Functionalization Route.” 61, no. 7 (July 2012): 1127–35. doi:10.1002/pi.4190.
Pages:1127-1135

Publication: Polymer International

Equipe : Génie Pharmacotechnique
Date : 2012




Preparation of vitamin E loaded nanocapsules by the nanoprecipitation method: From laboratory scale to large scale using a membrane contactor

Khayata, N., W. Abdelwahed, M.F. Chehna, C. Charcosset, and H. Fessi.
“Preparation of Vitamin E Loaded Nanocapsules by the Nanoprecipitation Method: From Laboratory Scale to Large Scale Using a Membrane Contactor.” 423, no. 2 (February 2012): 419–27. doi:10.1016/j.ijpharm.2011.12.016.
Pages:419-427

Publication: International Journal of Pharmaceutics

Equipe : Génie Pharmacotechnique
Date : 2012




Preparation, Characterization and Applications of Liposomes: State of the Art

Laouini, A., C. Jaafar-Maalej, I. Limayem-Blouza, S. Sfar, C. Charcosset, and H. Fessi.
“Preparation, Characterization and Applications of Liposomes: State of the Art.” 1, no. 2 (December 1, 2012): 147–68. doi:10.1166/jcsb.2012.1020.
Pages:147-168

Publication: Journal of Colloid Science and Biotechnology

Equipe : Génie Pharmacotechnique
Date : 2012




Profils des teneurs en eau de la patate douce durant son séchage convectif

Ouoba, H., F. Zougmore, B. Naon, and Hélène Desmorieux.
“Profils Des Teneurs En Eau de La Patate Douce Durant Son Séchage Convectif.” 13, no. 2 (2012): 201–5.
Pages:201-205

Publication: Rev.CAMES-Série A

Equipe : PES
Date : 2012




Pseudo-spectral methods for the spatial symplectic reduction of open systems of conservation laws

Moulla, R., L. Lefévre, and B. Maschke.
“Pseudo-Spectral Methods for the Spatial Symplectic Reduction of Open Systems of Conservation Laws.” 231, no. 4 (February 2012): 1272–92. doi:10.1016/j.jcp.2011.10.008.
Pages:1272-1292

Publication: Journal of Computational Physics

Equipe : DYCOP
Date : 2012




Reachability-based feedback control of crystal size distribution in batch crystallization processes

In the paper, we investigate the controllability of crystallization processes by reachability analysis. Crystallization processes are governed by hyperbolic partial differential equations. Given a desired crystal size distribution, we study its reachability by the temperature control from the initial condition without seeding. When the desired crystal size distribution is reachable, we construct an admissible control steering the state to the desired distribution. Our construction is developed based on the discretized model. To ensure that the desired distribution be reached facing model uncertainty, we propose an output feedback control law to correct errors resulted from disturbed parameters of the model.
Zhang, K., M. Nadri, and C.-Z. Xu.
“Reachability-Based Feedback Control of Crystal Size Distribution in Batch Crystallization Processes.” 22, no. 10 (2012): 1856–64. doi:10.1016/j.jprocont.2012.10.002.
Pages:1856-1864

Publication: Journal of Process Control

Equipe : SNLEP
Date : 2012




Robust fault detection and estimation for descriptor systems based on multi-models concept

This paper addresses the robust fault detection and estimation problem of nonlinear descriptor system with unknown inputs observers. The considered nonlinear descriptor system is transformed into an equivalent multi-models form by using the Takagi-Sugeno (T-S) approach. Two cases are considered: the first one deals with the multi-models based on measurable decision variables and the second one assumes that these decision variables are unmeasurable. Then, a residual generator based on an unknown observer is designed for both fault detection and estimation. Stability analysis and gain matrices determination are performed by resolving a set of Linear Matrices Inequalities (LMIs) for both cases. The performances of the proposed fault detection and estimation method is successfully applied to an electrical circuit.
Hamdi, Habib, Mickael Rodrigues, Chokri Mechmeche, and Naceur Benhadj Braiek.
“Robust Fault Detection and Estimation for Descriptor Systems Based on Multi-Models Concept.” 10, no. 6 (December 1, 2012): 1260–66. doi:10.1007/s12555-012-0622-z.
Pages:1260-1266

Publication: International Journal of Control, Automation and Systems

Equipe : SNLEP
Date : 2012




Role of Structure and Chemistry in Controlling Separations of CO2/CH4 and CO2/CH4/CO Mixtures over Honeycomb MOFs with Coordinatively Unsaturated Metal Sites

A systematic study of the effect of coordinatively unsaturated sites (cus) in the separation of CO2/CH4 and CO/CO2/CH4 mixtures on CPO-27-M (M = Ni, Co and Zn) and STA-12-Ni metal-organic frameworks was carried out using gravimetric and breakthrough experiments. The separation selectivity and the working capacity of these structures were evaluated as important performance indicators for CO2 separations by PSA. The results demonstrate a remarkable influence of coordinatively unsaturated sites on the selectivity and the working capacity. Particularly, the high affinity of CPO-27-Ni and CPO-27-Co for CO2 leads to a low working capacity for CO2 (because regeneration of the adsorbents is difficult), but a high CO2/CH4 selectivity. With a ternary CO/CO2/CH4 feed mixture, CPO-27-Ni and Co prefer the adsorption of CO over CO2, due to the strong specific interaction of CO with cus. Surprisingly, STA-12-Ni does not exhibit the same behavior: it is selective for the adsorption of CO2 in a ternary mixture, just like CPO-27-Zn. Among the four MOFs tested in this study, CPO-27-Zn presents the best compromise between the working capacity and the CO2/CH4 and CO2/CO selectivities. The results are discussed in terms of the coordination chemistry of the coordinatively unsaturated metal sites, their acid-base properties and their accessibility.
García, Edder J., John P. S. Mowat, Paul A. Wright, Javier Pérez-Pellitero, Christian Jallut, and Gerhard D. Pirngruber.
“Role of Structure and Chemistry in Controlling Separations of CO2/CH4 and CO2/CH4/CO Mixtures over Honeycomb MOFs with Coordinatively Unsaturated Metal Sites.” 116, no. 50 (December 20, 2012): 26636–48. doi:10.1021/jp309526k.
Pages:26636-26648

Publication: The Journal of Physical Chemistry C

Equipe : DYCOP
Date : 2012




Sea water desalination by dynamic layer melt crystallization: Parametric study of the freezing and sweating steps

Rich, Anouar, Youssef Mandri, Denis Mangin, Alain Rivoire, Souad Abderafi, Christine Bebon, Naoual Semlali, et al.
“Sea Water Desalination by Dynamic Layer Melt Crystallization: Parametric Study of the Freezing and Sweating Steps.” 342, no. 1 (2012): 110–16. doi:10.1016/j.jcrysgro.2011.03.061.
Pages:110-116

Publication: Journal of Crystal Growth

Equipe : PES
Date : 2012




SHG Active Fe(IO3)3 Particles: From Spherical Nanocrystals to Urchin-Like Microstructures through the Additive-Mediated Microemulsion Route

Ladj, Rachid, Moustafa El Kass, Yannick Mugnier, Ronan Le Dantec, Hatem Fessi, Christine Galez, and Abdelhamid Elaissari.
“SHG Active Fe(IO3)3 Particles: From Spherical Nanocrystals to Urchin-Like Microstructures through the Additive-Mediated Microemulsion Route.” 12, no. 11 (November 7, 2012): 5387–95. doi:10.1021/cg3009915.
Pages:5387-5395

Publication: Crystal Growth & Design

Equipe : Génie Pharmacotechnique
Date : 2012




Shunt Concept for Specific Active Transport Using Enzymatic Membranes: Review and Prospects

Charcosset, Catherine, Bernard Perrin, Bernard Maïsterrena, and Koffi Fiaty.
“Shunt Concept for Specific Active Transport Using Enzymatic Membranes: Review and Prospects.” 41, no. 2 (April 2012): 126–42. doi:10.1080/15422119.2011.580821.
Pages:126-142

Publication: Separation & Purification Reviews

Equipe : Multi-équipes
Date : 2012




Shunt Concept for Specific Active Transport Using Enzymatic Membranes: Review and Prospects

Artifical enzymatic membranes (AEMs) were conceived with the aim of replicating the active transport found in vivo. The shunt concept has recently emerged from the use of two enzymes catalysing two opposite reactions occurring on both parts of a porous charged membrane (+ or −) and able to specifically add/remove (or the contrary) a charged group (+ or −) on the selected molecule to be transported. Historically, the Phosphatase (P)/Kinase (K) couple (or its inverse), frequently found in nature, was selected for creating these shunts. Modelling of these transports was realized using the Nernst-Planck equation. In parallel, experimental studies were conducted proving that these shunt topologies, involving enzymatic membranes, lead to specific and active solute transports at physiological temperature and pressure. Issuing from this concept, recent technological prospects, such as the specific separation and concentration of (L) substrate from the (D/L) racemic mixture and the selective transport of neutral molecules by electrophoresis, are presented. This review presents the main results obtained using polymeric membranes linked to enzymes with the aim of replicating the active transport found in vivo.
Charcosset, Catherine, Bernard Perrin, Bernard Maïsterrena, and Koffi Fiaty.
“Shunt Concept for Specific Active Transport Using Enzymatic Membranes: Review and Prospects.” 41, no. 2 (2012): 126–42. doi:10.1080/15422119.2011.580821.
Pages:126-142

Publication: Separation & Purification Reviews

Equipe : Génie Pharmacotechnique
Date : 2012




Silica-based nanoparticles for biomedical applications

Bitar, Ahmad, Nasir M. Ahmad, Hatem Fessi, and Abdelhamid Elaissari.
“Silica-Based Nanoparticles for Biomedical Applications.” 17, no. 19–20 (October 2012): 1147–54. doi:10.1016/j.drudis.2012.06.014.
Pages:1147-1154

Publication: Drug Discovery Today

Equipe : Génie Pharmacotechnique
Date : 2012




Stabilisation d’émulsions de silicone fonctionnalisée par des cyclodextrines

Noomen, A., Hbaieb, S., Chevalier, Y., and Kalfat, R.
“Stabilisation D’émulsions de Silicone Fonctionnalisée Par Des Cyclodextrines.” 14 (2012): 47–56.
Pages:47-56

Publication: J. Soc. Chim. Tunisie

Equipe : Génie Pharmacotechnique
Date : 2012




Stability of systems with the Duhem hysteresis operator: The dissipativity approach

In this paper, we discuss the dissipativity property of the counterclockwise Duhem operator. Sufficient conditions on the functions which define the Duhem operator are given such that the Duhem operator has counterclockwise input–output dynamics. In particular, an explicit construction of the storage functions satisfying the counterclockwise dissipation inequality is given. The constructed storage function is also related to the underlying anhysteresis function which is commonly used to describe hysteresis in magnetic materials. The results can thus facilitate analysis of systems with the counterclockwise Duhem operator via the dissipativity approach.
Jayawardhana, Bayu, Ruiyue Ouyang, and Vincent Andrieu.
“Stability of Systems with the Duhem Hysteresis Operator: The Dissipativity Approach.” 48, no. 10 (October 2012): 2657–62. doi:10.1016/j.automatica.2012.06.069.
Pages:2657-2662

Publication: Automatica

Equipe : SNLEP
Date : 2012




Stability study and lyophilization of vitamin E-loaded nanocapsules prepared by membrane contactor

Khayata, N., W. Abdelwahed, M.F. Chehna, C. Charcosset, and H. Fessi.
“Stability Study and Lyophilization of Vitamin E-Loaded Nanocapsules Prepared by Membrane Contactor.” 439, no. 1–2 (December 2012): 254–59. doi:10.1016/j.ijpharm.2012.09.032.
Pages:254-259

Publication: International Journal of Pharmaceutics

Equipe : Génie Pharmacotechnique
Date : 2012




State and Unknown Inputs Estimations for Multi-Models Descriptor Systems

Mechmeche, Chokri, Hamdi Habib, Mickael Rodrigues, and Naceur BenHadjBraiek.
“State and Unknown Inputs Estimations for Multi-Models Descriptor Systems.” 2, no. 3 (August 31, 2012): 86–93. doi:10.5923/j.ajcam.20120203.04.
Pages:86-93

Publication: American Journal of Computational and Applied Mathematics

Equipe : SNLEP
Date : 2012




Synthesis and Characterization of Thermally and Glucose-Sensitive Poly N-Vinylcaprolactam-Based Microgels

Bitar, Ahmad, Hatem Fessi, and Abdelhamid Elaissari.
“Synthesis and Characterization of Thermally and Glucose-Sensitive Poly <I>N</I>-Vinylcaprolactam-Based Microgels.” 8, no. 5 (October 1, 2012): 709–719. doi:10.1166/jbn.2012.1439.
Pages:709-719

Publication: Journal of Biomedical Nanotechnology

Equipe : Génie Pharmacotechnique
Date : 2012




Theranostic applications of nanoparticles in cancer

Ahmed, Naveed, Hatem Fessi, and Abdelhamid Elaissari.
“Theranostic Applications of Nanoparticles in Cancer.” 17, no. 17–18 (September 2012): 928–34. doi:10.1016/j.drudis.2012.03.010.
Pages:928-934

Publication: Drug Discovery Today

Equipe : Génie Pharmacotechnique
Date : 2012




Thermally-Sensitive and Magnetic Poly(N-Vinylcaprolactam)-Based Nanogels by Inverse Miniemulsion Polymerization

Medeiros, Simone F., Amilton M. Santos, Hatem Fessi, and Abdelhamid Elaissari.
“Thermally-Sensitive and Magnetic Poly(N-Vinylcaprolactam)-Based Nanogels by Inverse Miniemulsion Polymerization.” 1, no. 1 (June 1, 2012): 99–112. doi:10.1166/jcsb.2012.1002.
Pages:99-112

Publication: Journal of Colloid Science and Biotechnology

Equipe : Génie Pharmacotechnique
Date : 2012